Show simple item record

dc.contributor.author
Quitterer, Ursula
dc.contributor.author
AbdAlla, Said
dc.date.accessioned
2020-03-23T14:34:41Z
dc.date.available
2020-01-20T21:03:21Z
dc.date.available
2020-01-27T15:42:43Z
dc.date.available
2020-03-23T14:34:41Z
dc.date.issued
2020-04
dc.identifier.issn
1043-6618
dc.identifier.issn
1096-1186
dc.identifier.other
10.1016/j.phrs.2019.04.014
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/392379
dc.identifier.doi
10.3929/ethz-b-000392379
dc.description.abstract
With ageing of the global society, the frequency of ageing-related neurodegenerative diseases such as Alzheimer`s disease (AD) is on the rise worldwide. Currently, there is no cure for AD, and the four drugs approved for AD only have very small effects on AD symptoms. Consequently, there are enormous efforts worldwide to identify new targets for treatment of AD. Approaches that interfere with classical neuropathologic features of AD, such as extracellular senile plaques formed of aggregated amyloid-beta (Abeta), and intracellular neurofibrillary tangles of hyperphosphorylated tau have not been successful so far. In search for a treatment approach of AD, we found that inhibition of the angiotensin-converting enzyme (ACE) by a centrally acting ACE inhibitor retards symptoms of neurodegeneration, Abeta plaque formation and tau hyperphosphorylation in experimental models of AD. Our approach is currently being investigated in a clinical setting. Initial evidence with AD patients shows that a brain-penetrating ACE inhibitor counteracts the process of neurodegeneration and dementia. Moreover, centrally acting ACE inhibitors given in addition to the standard therapy, cholinesterase inhibition, can improve cognitive function of AD patients for several months. This is one of the most promising results for AD treatment since more than a decade.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Angiotensin-converting enzyme
en_US
dc.subject
AGTR1
en_US
dc.subject
Alzheimer's disease
en_US
dc.subject
Neurodegeneration
en_US
dc.subject
Dementia
en_US
dc.subject
Amyloid-beta
en_US
dc.subject
Tau
en_US
dc.title
Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2019-04-13
ethz.journal.title
Pharmacological research
ethz.journal.volume
154
en_US
ethz.journal.abbreviated
Pharmacol. res. (Print)
ethz.pages.start
104230
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03735 - Quitterer, Ursula M. / Quitterer, Ursula M.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03735 - Quitterer, Ursula M. / Quitterer, Ursula M.
en_US
ethz.date.deposited
2020-01-20T21:03:29Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-03-23T14:35:00Z
ethz.rosetta.lastUpdated
2020-03-23T14:35:00Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Improvements%20of%20symptoms%20of%20Alzheimer%60s%20disease%20by%20inhibition%20of%20the%20angiotensin%20system&rft.jtitle=Pharmacological%20research&rft.date=2020-04&rft.volume=154&rft.spage=104230&rft.issn=1043-6618&1096-1186&rft.au=Quitterer,%20Ursula&AbdAlla,%20Said&rft.genre=article&
 Search via SFX

Files in this item

Thumbnail

Publication type

Show simple item record