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dc.contributor.author
Filice, Federica
dc.contributor.author
Schwaller, Beat
dc.contributor.author
Michel, Tanja M.
dc.contributor.author
Grünblatt, Edna
dc.date.accessioned
2020-02-10T09:21:38Z
dc.date.available
2020-02-08T03:12:27Z
dc.date.available
2020-02-10T09:21:38Z
dc.date.issued
2020
dc.identifier.other
10.1186/s13229-020-0314-0
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/397708
dc.identifier.doi
10.3929/ethz-b-000397708
dc.description.abstract
Autism spectrum disorders (ASD) are persistent conditions resulting from disrupted/altered neurodevelopment. ASD multifactorial etiology—and its numerous comorbid conditions—heightens the difficulty in identifying its underlying causes, thus obstructing the development of effective therapies. Increasing evidence from both animal and human studies suggests an altered functioning of the parvalbumin (PV)-expressing inhibitory interneurons as a common and possibly unifying pathway for some forms of ASD. PV-expressing interneurons (short: PVALB neurons) are critically implicated in the regulation of cortical networks’ activity. Their particular connectivity patterns, i.e., their preferential targeting of perisomatic regions and axon initial segments of pyramidal cells, as well as their reciprocal connections, enable PVALB neurons to exert a fine-tuned control of, e.g., spike timing, resulting in the generation and modulation of rhythms in the gamma range, which are important for sensory perception and attention. New methodologies such as induced pluripotent stem cells (iPSC) and genome-editing techniques (CRISPR/Cas9) have proven to be valuable tools to get mechanistic insight in neurodevelopmental and/or neurodegenerative and neuropsychiatric diseases. Such technological advances have enabled the generation of PVALB neurons from iPSC. Tagging of these neurons would allow following their fate during the development, from precursor cells to differentiated (and functional) PVALB neurons. Also, it would enable a better understanding of PVALB neuron function, using either iPSC from healthy donors or ASD patients with known mutations in ASD risk genes. In this concept paper, the strategies hopefully leading to a better understanding of PVALB neuron function(s) are briefly discussed. We envision that such an iPSC-based approach combined with emerging (genetic) technologies may offer the opportunity to investigate in detail the role of PVALB neurons and PV during “neurodevelopment ex vivo.”
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
PubMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Parvalbumin
en_US
dc.subject
Induced pluripotent stem cells
en_US
dc.subject
Autism spectrum disorder
en_US
dc.subject
Schizophrenia
en_US
dc.subject
CRISPR-Cas9 technology
en_US
dc.subject
GABAergic
en_US
dc.subject
Interneuron
en_US
dc.title
Profiling parvalbumin interneurons using iPSC: challenges and perspectives for Autism Spectrum Disorder (ASD)
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-01-29
ethz.journal.title
Molecular Autism
ethz.journal.volume
11
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
10
en_US
ethz.size
5 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-02-08T03:12:40Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-02-10T09:21:49Z
ethz.rosetta.lastUpdated
2021-02-15T07:53:40Z
ethz.rosetta.versionExported
true
ethz.COinS
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