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dc.contributor.author
Müller, Madlen
dc.contributor.author
Fazi, Francesco
dc.contributor.author
Ciaudo, Constance
dc.date.accessioned
2020-02-14T12:05:46Z
dc.date.available
2020-02-14T03:18:22Z
dc.date.available
2020-02-14T12:05:46Z
dc.date.issued
2020-01
dc.identifier.issn
2296634X
dc.identifier.issn
2296-634X
dc.identifier.other
10.3389/fcell.2019.00360
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/399325
dc.identifier.doi
10.3929/ethz-b-000399325
dc.description.abstract
The highly conserved Argonaute protein family members play a central role in the regulation of gene expression networks, orchestrating the establishment and the maintenance of cell identity throughout the entire life cycle, as well as in several human disorders, including cancers. Four functional Argonaute proteins (AGO1–4), with high structure similarity, have been described in humans and mice. Interestingly, only AGO2 is robustly expressed during human and mouse early development, in contrast to the other AGOs. Consequently, AGO2 is indispensable for early development in vivo and in vitro. Here, we review the roles of Argonaute proteins during early development by focusing on the interplay between specific domains of the protein and their function. Moreover, we report recent works highlighting the importance of AGO posttranslational modifications in cancer.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Research Foundation
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
argonaute proteins
en_US
dc.subject
expression
en_US
dc.subject
structure
en_US
dc.subject
posttranslational modifications
en_US
dc.subject
development
en_US
dc.subject
cancer
en_US
dc.title
Argonaute Proteins: From Structure to Function in Development and Pathological Cell Fate Determination
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-01-22
ethz.journal.title
Frontiers in Cell and Developmental Biology
ethz.journal.volume
7
en_US
ethz.journal.abbreviated
Front. cell dev. biol.
ethz.pages.start
360
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Canonical and non-canonical functions of RNA interference proteins during mouse early development
en_US
ethz.identifier.scopus
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.grant.agreementno
173120
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.date.deposited
2020-02-14T03:18:28Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-02-14T12:05:57Z
ethz.rosetta.lastUpdated
2020-02-14T12:05:57Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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