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dc.contributor.author
Carlevaro-Fita, Joana
dc.contributor.author
Lanzós, Andrés
dc.contributor.author
Feuerbach, Lars
dc.contributor.author
Hong, Chen
dc.contributor.author
Mas-Ponte, David
dc.contributor.author
Pedersen, Jakob S.
dc.contributor.author
PCAWG Drivers and Functional Interpretation Group
dc.contributor.author
Johnson, Rory
dc.contributor.author
PCAWG Consortium
dc.date.accessioned
2020-02-14T07:36:35Z
dc.date.available
2020-02-14T03:23:19Z
dc.date.available
2020-02-14T07:36:35Z
dc.date.issued
2020
dc.identifier.issn
23993642
dc.identifier.other
10.1038/s42003-019-0741-7
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/399368
dc.identifier.doi
10.3929/ethz-b-000399368
dc.description.abstract
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive tumorigenesis, and whether such functions could be conserved during evolution. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we introduce the Cancer LncRNA Census (CLC), a compilation of 122 GENCODE lncRNAs with causal roles in cancer phenotypes. In contrast to existing databases, CLC requires strong functional or genetic evidence. CLC genes are enriched amongst driver genes predicted from somatic mutations, and display characteristic genomic features. Strikingly, CLC genes are enriched for driver mutations from unbiased, genome-wide transposon-mutagenesis screens in mice. We identified 10 tumour-causing mutations in orthologues of 8 lncRNAs, including LINC-PINT and NEAT1, but not MALAT1. Thus CLC represents a dataset of high-confidence cancer lncRNAs. Mutagenesis maps are a novel means for identifying deeply-conserved roles of lncRNAs in tumorigenesis.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-02-05
ethz.journal.title
Communications Biology
ethz.journal.volume
3
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
56
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-02-14T03:23:40Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-02-14T07:36:46Z
ethz.rosetta.lastUpdated
2020-02-14T07:36:46Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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