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dc.contributor.author
Clerc, Melanie
dc.contributor.author
Babayan, Simon A.
dc.contributor.author
Fenton, Andy
dc.contributor.author
Pedersen, Amy B.
dc.date.accessioned
2020-03-12T13:57:37Z
dc.date.available
2020-03-11T09:30:27Z
dc.date.available
2020-03-12T13:57:37Z
dc.date.issued
2019-04
dc.identifier.issn
2213-2244
dc.identifier.other
10.1016/j.ijppaw.2019.03.004
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/404298
dc.identifier.doi
10.3929/ethz-b-000404298
dc.description.abstract
The role of the host immune system in determining parasite burdens and mediating within-host parasite interactions has traditionally been studied in highly controlled laboratory conditions. This does, however, not reflect the diversity of individuals living in nature, which is often characterised by significant variation in host demography, such as host age, sex, and infection history. Whilst studies using wild hosts and parasites are beginning to give insights into the complex relationships between immunity, parasites and host demography, the cause-and-effect relationships often remain unknown due to a lack of high resolution, longitudinal data. We investigated the infection dynamics of two interacting gastrointestinal parasites of wild wood mice (Apodemus sylvaticus), the nematode Heligmosomoides polygyrus and the coccidian Eimeria hungaryensis, in order to assess the links between infection, coinfection, and the immunological dynamics of two antibodies (IgG1 and IgA). In an anthelmintic treatment experiment, mice were given a single oral dose of an anthelmintic treatment, or control dose, and then subsequently followed longitudinally over a period of 7–15 days to measure parasite burdens and antibody levels. Anthelmintic treatment successfully reduced burdens of H. polygyrus, but had no significant impact on E. hungaryensis. Treatment efficacy was driven by host age, with adult mice showing stronger reductions in burdens compared to younger mice. We also found that the relationship between H. polygyrus-specific IgG1 and nematode burden changed from positive in young mice to negative in adult mice. Our results highlight that a key host demographic factor like age could account for large parts of the variation in nematode burden and nematode-specific antibody levels observed in a naturally infected host population, possibly due to different immune responses in young vs. old animals. Given the variable success in community-wide de-worming programmes in animals and humans, accounting for the age-structure of a population could increase overall efficacy.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Anthelmintic treatment
en_US
dc.subject
Age-dependent immunity
en_US
dc.subject
Eimeria hungaryensis
en_US
dc.subject
Heligmosomoides polygyrus
en_US
dc.subject
Within-host interaction
en_US
dc.subject
Wild immunology
en_US
dc.title
Age affects antibody levels and anthelmintic treatment efficacy in a wild rodent
en_US
dc.type
Journal Article
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-03-14
ethz.journal.title
International Journal for Parasitology. Parasites and Wildlife
ethz.journal.volume
8
en_US
ethz.pages.start
240
en_US
ethz.pages.end
247
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::09583 - Sunagawa, Shinichi / Sunagawa, Shinichi
ethz.identifier.orcidWorkCode
70368364
ethz.date.deposited
2020-03-11T09:30:36Z
ethz.source
FORM
ethz.eth
no
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-03-12T13:57:48Z
ethz.rosetta.lastUpdated
2021-02-15T08:44:35Z
ethz.rosetta.versionExported
true
ethz.COinS
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