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dc.contributor.author
Montalvo-Jaramillo, Cristian I.
dc.contributor.author
Pliego-Carrillo, Adriana C.
dc.contributor.author
Peña-Castillo, Miguel Á.
dc.contributor.author
Echeverría, Juan C.
dc.contributor.author
Becerril-Villanueva, Enrique
dc.contributor.author
Pavón, Lenin
dc.contributor.author
Ayala-Yáñez, Rodrigo
dc.contributor.author
González-Camarena, Ramón
dc.contributor.author
Berg, Karsten
dc.contributor.author
Wessel, Niels
dc.contributor.author
Pacheco-López, Gustavo
dc.contributor.author
Reyes-Lagos, José J.
dc.date.accessioned
2020-03-20T08:29:01Z
dc.date.available
2020-03-19T02:38:29Z
dc.date.available
2020-03-20T08:29:01Z
dc.date.issued
2020-03
dc.identifier.other
10.1016/j.heliyon.2020.e03485
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/405659
dc.identifier.doi
10.3929/ethz-b-000405659
dc.description.abstract
Fetal heart rate variability (fHRV) is an essential source of information to monitor fetal well-being during pregnancy. This study aimed to apply a nonlinear approach, known as symbolic dynamics (SD), for comparing human fHRV in the third trimester of pregnancy during active fetal state (TT) and active labor at term (P). We performed a longitudinal, prospective, descriptive, and comparative study composed of 42 longitudinal recordings of 5-minutes of fetal heartbeat interval series. Recordings were collected from 21 low-risk, healthy, pregnant women attending the Maternal and Child Research Center (CIMIGen), Mexico City. We calculated relevant linear parameters of fHRV between TT and P stages, such as the percentage of differences between adjacent RR intervals >5 ms (PRR5, related to vagal modulations) and other SD parameters such as the percentage of no variations between three successive symbols (%0V, reflects sympathetic modulations) and the probability of low variability with a threshold of 4 ms (POLVAR4, associated with a low variability). We identified statistical differences for PRR5 between TT and P (37.13% [28.47–47.60%] vs. 28.84% [19.36–36.76%], p = 0.03), respectively. Also, for 0V% (65.66% [59.01–71.80%] vs. 71.14% [65.94–75.87%], p = 0.03) and for POLVAR4 values (0.06 [0.04–0.11] vs. 0.15 [0.09–0.24], p = 0.002), respectively. Our results indicate that during parturition, the short-term fetal fHRV is decreased, showing a decreased vagal modulations and higher adrenergic response of the heart. These autonomic modifications may result from the fetal response to the stressful inflammatory challenge of labor. We thus confirmed that the analysis of the SD applied to fHRV time series could be a potential clinical biomarker to differentiate the fetal autonomic cardiac condition at different stages of pregnancy.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Nonlinear signal processing
en_US
dc.subject
Biomedical engineering
en_US
dc.subject
Medical physics
en_US
dc.subject
Nervous system
en_US
dc.subject
Obstetrics
en_US
dc.subject
Symbolic dynamics
en_US
dc.subject
Term birth
en_US
dc.subject
Fetal heart rate variability
en_US
dc.subject
Labor
en_US
dc.title
Comparison of fetal heart rate variability by symbolic dynamics at the third trimester of pregnancy and low-risk parturition
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2020-03-12
ethz.journal.title
Heliyon
ethz.journal.volume
6
en_US
ethz.journal.issue
3
en_US
ethz.pages.start
e03485
en_US
ethz.size
8 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-03-19T02:38:37Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-03-20T08:29:22Z
ethz.rosetta.lastUpdated
2021-02-15T09:12:14Z
ethz.rosetta.versionExported
true
ethz.COinS
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