Zur Kurzanzeige

dc.contributor.author
Mukhtar, Tanzila
dc.contributor.author
Breda, Jeremie
dc.contributor.author
Grison, Alice
dc.contributor.author
Karimaddini, Zahra
dc.contributor.author
Grobecker, Pascal
dc.contributor.author
Iber, Dagmar
dc.contributor.author
Beisel, Christian
dc.contributor.author
van Nimwegen, Erik
dc.contributor.author
Taylor, Verdon
dc.date.accessioned
2020-03-27T09:58:19Z
dc.date.available
2020-03-27T05:23:19Z
dc.date.available
2020-03-27T09:58:19Z
dc.date.issued
2020
dc.identifier.issn
2045-2322
dc.identifier.other
10.1038/s41598-020-61490-5
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/406778
dc.identifier.doi
10.3929/ethz-b-000406778
dc.description.abstract
Neural stem cells (NSCs) generate neurons of the cerebral cortex with distinct morphologies and functions. How specific neuron production, differentiation and migration are orchestrated is unclear. Hippo signaling regulates gene expression through Tead transcription factors (TFs). We show that Hippo transcriptional coactivators Yap1/Taz and the Teads have distinct functions during cortical development. Yap1/Taz promote NSC maintenance and Satb2+ neuron production at the expense of Tbr1+ neuron generation. However, Teads have moderate effects on NSC maintenance and do not affect Satb2+ neuron differentiation. Conversely, whereas Tead2 blocks Tbr1+ neuron formation, Tead1 and Tead3 promote this early fate. In addition, we found that Hippo effectors regulate neuronal migration to the cortical plate (CP) in a reciprocal fashion, that ApoE, Dab2 and Cyr61 are Tead targets, and these contribute to neuronal fate determination and migration. Our results indicate that multifaceted Hippo signaling is pivotal in different aspects of cortical development.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Tead transcription factors differentially regulate cortical development
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-03-13
ethz.journal.title
Scientific Reports
ethz.journal.volume
10
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Sci Rep
ethz.pages.start
4625
en_US
ethz.size
19 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03791 - Iber, Dagmar / Iber, Dagmar
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03791 - Iber, Dagmar / Iber, Dagmar
ethz.date.deposited
2020-03-27T05:23:36Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-03-27T09:58:31Z
ethz.rosetta.lastUpdated
2021-02-15T09:41:52Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Tead%20transcription%20factors%20differentially%20regulate%20cortical%20development&rft.jtitle=Scientific%20Reports&rft.date=2020&rft.volume=10&rft.issue=1&rft.spage=4625&rft.issn=2045-2322&rft.au=Mukhtar,%20Tanzila&Breda,%20Jeremie&Grison,%20Alice&Karimaddini,%20Zahra&Grobecker,%20Pascal&rft.genre=article&rft_id=info:doi/10.1038/s41598-020-61490-5&
 Printexemplar via ETH-Bibliothek suchen

Dateien zu diesem Eintrag

Thumbnail

Publikationstyp

Zur Kurzanzeige