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dc.contributor.author
Hartinger, Stella M.
dc.contributor.author
Nuño, Nestor
dc.contributor.author
Hattendorf, Jan
dc.contributor.author
Verastegui, Hector
dc.contributor.author
Karlen, Walter
dc.contributor.author
Ortiz, Mariela
dc.contributor.author
Mäusezahl, Daniel
dc.date.accessioned
2020-04-09T06:33:01Z
dc.date.available
2020-04-09T06:04:11Z
dc.date.available
2020-04-09T06:33:01Z
dc.date.issued
2020-04-02
dc.identifier.issn
1471-2288
dc.identifier.other
10.1186/s12874-020-00950-y
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/409106
dc.identifier.doi
10.3929/ethz-b-000409106
dc.description.abstract
BACKGROUND Exposure to unhealthy environments and inadequate child stimulation are main risk factors that affect children's health and wellbeing in low- and middle-income countries. Interventions that simultaneously address several risk factors at the household level have great potential to reduce these negative effects. We present the design and baseline findings of a cluster-randomised controlled trial to evaluate the impact of an integrated home-environmental intervention package and an early child development programme to improve diarrhoea, acute respiratory infections and childhood developmental outcomes in children under 36 months of age living in resource-limited rural Andean Peru. METHODS We collected baseline data on children's developmental performance, health status and demography as well as microbial contamination in drinking water. In a sub-sample of households, we measured indoor kitchen 24-h air concentration levels of carbon monoxide (CO) and fine particulate matter (PM2.5) and CO for personal exposure. RESULTS We recruited and randomised 317 children from 40 community-clusters to four study arms. At baseline, all arms had similar health and demographic characteristics, and the developmental status of children was comparable between arms. The analysis revealed that more than 25% of mothers completed primary education, a large proportion of children were stunted and diarrhoea prevalence was above 18%. Fifty-two percent of drinking water samples tested positive for thermo-tolerant coliforms and the occurrence of E.coli was evenly distributed between arms. The mean levels of kitchen PM2.5 and CO concentrations were 213 μg/m3 and 4.8 ppm, respectively. CONCLUSIONS The trial arms are balanced with respect to most baseline characteristics, such as household air and water pollution, and child development. These results ensure the possible estimation of the trial effectiveness. This trial will yield valuable information for assessing synergic, rational and cost-effective benefits of the combination of home-based interventions. TRIAL REGISTRY ISRCTN-26548981.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Cluster-randomised trial
en_US
dc.subject
Integrated home-based interventions
en_US
dc.subject
Early child development
en_US
dc.subject
Diarrhoea
en_US
dc.subject
Respiratory infections
en_US
dc.subject
Kitchen hygiene
en_US
dc.subject
Househld air pollution
en_US
dc.subject
Household water treatment
en_US
dc.subject
Improved biomass cookstoves
en_US
dc.subject
Peru
en_US
dc.subject
Pneumonia
en_US
dc.title
A factorial cluster-randomised controlled trial combining home-environmental and early child development interventions to improve child health and development: rationale, trial design and baseline findings
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
BMC Medical Research Methodology
ethz.journal.volume
20
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
BMC med. res. methodol. (Online)
ethz.pages.start
73
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Intelligent Point-of-Care Monitoring: A Swiss Army Knife Approach to mHealth
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::09533 - Karlen, Walter (SNF-Förderprofessur) / Karlen, Walter (SNF-Förderprofessur)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::09533 - Karlen, Walter (SNF-Förderprofessur) / Karlen, Walter (SNF-Förderprofessur)
en_US
ethz.grant.agreementno
150640
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.date.deposited
2020-04-09T06:04:20Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-04-09T06:33:12Z
ethz.rosetta.lastUpdated
2020-04-09T06:33:12Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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