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dc.contributor.author
Treyer, Valerie
dc.contributor.author
Gietl, Anton F.
dc.contributor.author
Suliman, Husam
dc.contributor.author
Gruber, Esmeralda
dc.contributor.author
Meyer, Rafael
dc.contributor.author
Buchmann, Andreas
dc.contributor.author
Johayem, Anass
dc.contributor.author
Unschuld, Paul G.
dc.contributor.author
Nitsch, Roger M.
dc.contributor.author
Buck, Alfred
dc.contributor.author
Ametamey, Simon M.
dc.contributor.author
Hock, Christoph
dc.date.accessioned
2020-06-29T10:28:07Z
dc.date.available
2020-05-06T02:35:06Z
dc.date.available
2020-05-07T09:59:05Z
dc.date.available
2020-06-29T10:28:07Z
dc.date.issued
2020
dc.identifier.issn
2162-3279
dc.identifier.other
10.1002/brb3.1632
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/413228
dc.identifier.doi
10.3929/ethz-b-000413228
dc.description.abstract
Introduction Metabotropic glutamate receptors play a critical role in the pathogenesis of Alzheimer's disease due to their involvement in processes of memory formation, neuroplasticity, and synaptotoxity. The objective of the current study was to study mGluR5 availability measured by [11C]‐ABP688 (ABP) in patients with clinically diagnosed Alzheimer's dementia (AD). Methods A bolus‐infusion protocol of [11C]‐ABP688 was applied in 9 subjects with AD and 10 cognitively healthy controls (Controls) to derive distribution volume estimates of mGluR5. Furthermore, we also estimated cerebral perfusion by averaging early frame signal of initial ABP bolus injection. Results Subjects with Alzheimer's dementia (mean age: 77.3/SD 5.7) were older than controls (mean age: 68.5/SD : 9.6) and scored lower on the MMSE (22.1/SD2.7 vs. 29.0/SD0.8). There were no overall differences in ABP signal. However, distribution volume ratio (DVR) for ABP was reduced in the bilateral hippocampus (AD: 1.34/SD : 0.40 vs. Control: 1.84/SD :0.31, p = .007) and the bilateral amygdala (AD:1.86/SD :0.26 vs. Control:2.33/SD :0.37 p = .006) in AD patients compared to controls. Estimate of cerebral blood flow was reduced in the bilateral hippocampus in AD (AD:0.75/SD :0.10 vs. Control:0.86/SD :0.09 p = .02). Conclusion Our findings demonstrate reduced mGluR5 binding in the hippocampus and amygdala in Alzheimer's dementia. Whether this is due to synaptic loss and/or consecutive reduction of potential binding sites or reflects disease inherent mechanisms remains to be elucidated in future studies.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
ABP688
en_US
dc.subject
Alzheimer's dementia
en_US
dc.subject
amygdala
en_US
dc.subject
hippocampus
en_US
dc.subject
metabolic glutamate receptor
en_US
dc.subject
mGLUR5
en_US
dc.title
Reduced uptake of [11C]‐ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer’s dementia
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-04-18
ethz.journal.title
Brain and Behavior
ethz.journal.volume
10
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Brain Behav
ethz.pages.start
e01632
en_US
ethz.size
11 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Hoboken, NJ
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
ethz.date.deposited
2020-05-06T02:35:10Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-06-29T10:28:33Z
ethz.rosetta.lastUpdated
2021-02-15T15:09:42Z
ethz.rosetta.versionExported
true
ethz.COinS
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