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dc.contributor.author
Ortega, Davi R.
dc.contributor.author
Yang, Wen
dc.contributor.author
Subramanian, Poorna
dc.contributor.author
Mann, Petra
dc.contributor.author
Kjær, Andreas
dc.contributor.author
Chen, Songye
dc.contributor.author
Watts, Kylie J.
dc.contributor.author
Pirbadian, Sahand
dc.contributor.author
Collins, David A.
dc.contributor.author
Kooger, Romain
dc.contributor.author
Kalyuzhnaya, Marina G.
dc.contributor.author
Ringgaard, Simon
dc.contributor.author
Briegel, Ariane
dc.contributor.author
Jensen, Grant J.
dc.date.accessioned
2020-05-07T08:53:04Z
dc.date.available
2020-05-07T02:51:18Z
dc.date.available
2020-05-07T08:53:04Z
dc.date.issued
2020
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/s41467-020-15736-5
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/413445
dc.identifier.doi
10.3929/ethz-b-000413445
dc.description.abstract
How complex, multi-component macromolecular machines evolved remains poorly understood. Here we reveal the evolutionary origins of the chemosensory machinery that controls flagellar motility in Escherichia coli. We first identify ancestral forms still present in Vibrio cholerae, Pseudomonas aeruginosa, Shewanella oneidensis and Methylomicrobium alcaliphilum, characterizing their structures by electron cryotomography and finding evidence that they function in a stress response pathway. Using bioinformatics, we trace the evolution of the system through γ-Proteobacteria, pinpointing key evolutionary events that led to the machine now seen in E. coli. Our results suggest that two ancient chemosensory systems with different inputs and outputs (F6 and F7) existed contemporaneously, with one (F7) ultimately taking over the inputs and outputs of the other (F6), which was subsequently lost.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Repurposing a chemosensory macromolecular machine
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-04-27
ethz.journal.title
Nature Communications
ethz.journal.volume
11
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
2041
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.date.deposited
2020-05-07T02:51:24Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-05-07T08:53:14Z
ethz.rosetta.lastUpdated
2024-02-02T10:51:46Z
ethz.rosetta.versionExported
true
ethz.COinS
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