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dc.contributor.author
Nastały, Paulina
dc.contributor.author
Purushothaman, Divya
dc.contributor.author
Marchesi, Stefano
dc.contributor.author
Poli, Alessandro
dc.contributor.author
Lendenmann, Tobias
dc.contributor.author
Kidiyoor, Gururaj Rao
dc.contributor.author
Beznoussenko, Galina V.
dc.contributor.author
Lavore, Stefania
dc.contributor.author
Romano, Orso Maria
dc.contributor.author
Poulikakos, Dimos
dc.contributor.author
Lagomarsino, Marco Cosentino
dc.contributor.author
Mironov, Alexander A.
dc.contributor.author
Ferrari, Aldo
dc.contributor.author
Maiuri, Paolo
dc.date.accessioned
2020-05-11T13:19:30Z
dc.date.available
2020-05-09T04:10:46Z
dc.date.available
2020-05-11T13:19:30Z
dc.date.issued
2020-12
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/s41467-020-15910-9
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/414003
dc.identifier.doi
10.3929/ethz-b-000414003
dc.description.abstract
Cell polarity refers to the intrinsic asymmetry of cells, including the orientation of the cytoskeleton. It affects cell shape and structure as well as the distribution of proteins and organelles. In migratory cells, front-rear polarity is essential and dictates movement direction. While the link between the cytoskeleton and nucleus is well-studied, we aim to investigate if front-rear polarity can be transmitted to the nucleus. We show that the knock-down of emerin, an integral protein of the nuclear envelope, abolishes preferential localization of several nuclear proteins. We propose that the frontally biased localization of the endoplasmic reticulum, through which emerin reaches the nuclear envelope, is sufficient to generate its observed bias. In primary emerin-deficient myoblasts, its expression partially rescues the polarity of the nucleus. Our results demonstrate that front-rear cell polarity is transmitted to the nucleus and that emerin is an important determinant of nuclear polarity.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-05-01
ethz.journal.title
Nature Communications
ethz.journal.volume
11
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
2122
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.date.deposited
2020-05-09T04:10:51Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-05-11T13:19:43Z
ethz.rosetta.lastUpdated
2024-02-02T10:52:59Z
ethz.rosetta.versionExported
true
ethz.COinS
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