
Open access
Author
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Date
2020-05Type
- Journal Article
Citations
Cited 13 times in
Web of Science
Cited 16 times in
Scopus
ETH Bibliography
yes
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Abstract
The sleep disorder narcolepsy is associated with symptoms related to either boundary state control that include excessive daytime sleepiness and sleep fragmentation, or rapid eye movement (REM) sleep features including cataplexy, sleep paralysis, hallucinations, and sleep-onset REM sleep events (SOREMs). Although the loss of Hypocretin/Orexin (Hcrt/Ox) peptides or their receptors have been associated with the disease, here we propose a circuit perspective of the pathophysiological mechanisms of these narcolepsy symptoms that encompasses brain regions, neuronal circuits, cell types, and transmitters beyond the Hcrt/Ox system. We further discuss future experimental strategies to investigate brain-wide mechanisms of narcolepsy that will be essential for a better understanding and treatment of the disease. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000416235Publication status
publishedExternal links
Journal / series
SleepVolume
Pages / Article No.
Publisher
Oxford University PressSubject
narcolepsy; cataplexy; hypocretins/orexins; neural circuitsOrganisational unit
09589 - Burdakov, Denis / Burdakov, Denis
09589 - Burdakov, Denis / Burdakov, Denis
More
Show all metadata
Citations
Cited 13 times in
Web of Science
Cited 16 times in
Scopus
ETH Bibliography
yes
Altmetrics