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dc.contributor.author
Zhang, Jie
dc.contributor.author
Vaga, Stafania
dc.contributor.author
Chumnanpuen, Pramote
dc.contributor.author
Kumar, Rahul
dc.contributor.author
Vemuri, Goutham N.
dc.contributor.author
Aebersold, Ruedi
dc.contributor.author
Nielsen, Jens
dc.date.accessioned
2018-06-07T15:44:35Z
dc.date.available
2017-06-09T17:22:41Z
dc.date.available
2018-06-07T15:44:35Z
dc.date.issued
2011-01
dc.identifier.other
10.1038/msb.2011.80
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/41693
dc.identifier.doi
10.3929/ethz-b-000041693
dc.description.abstract
Nutrient sensing and coordination of metabolic pathways are crucial functions for all living cells, but details of the coordination under different environmental conditions remain elusive. We therefore undertook a systems biology approach to investigate the interactions between the Snf1 and the target of rapamycin complex 1 (TORC1) in Saccharomyces cerevisiae. We show that Snf1 regulates a much broader range of biological processes compared with TORC1 under both glucose‐ and ammonium‐limited conditions. We also find that Snf1 has a role in upregulating the NADP+‐dependent glutamate dehydrogenase (encoded by GDH3) under derepressing condition, and therefore may also have a role in ammonium assimilation and amino‐acid biosynthesis, which can be considered as a convergence of Snf1 and TORC1 pathways. In addition to the accepted role of Snf1 in regulating fatty acid (FA) metabolism, we show that TORC1 also regulates FA metabolism, likely through modulating the peroxisome and β‐oxidation. Finally, we conclude that direct interactions between Snf1 and TORC1 pathways are unlikely under nutrient‐limited conditions and propose that TORC1 is repressed in a manner that is independent of Snf1.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publ. Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject
carbon metabolism
en_US
dc.subject
nitrogen metabolism
en_US
dc.subject
nutrient sensing
en_US
dc.subject
Snf1
en_US
dc.subject
TORC1
en_US
dc.title
Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
dc.date.published
2011-11-08
ethz.journal.title
Molecular Systems Biology
ethz.journal.volume
7
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
545
en_US
ethz.size
11 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
004931271
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf / Aebersold, Rudolf
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf / Aebersold, Rudolf
ethz.date.deposited
2017-06-09T17:22:45Z
ethz.source
ECIT
ethz.identifier.importid
imp59364eac0667031065
ethz.ecitpid
pub:69635
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-19T07:54:55Z
ethz.rosetta.lastUpdated
2018-11-07T11:31:05Z
ethz.rosetta.versionExported
true
ethz.COinS
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