The what, where, how and why of gene ontology - a primer for bioinformaticians
dc.contributor.author
du Plessis, Louis
dc.contributor.author
Škunca, Nives
dc.contributor.author
Dessimoz, Christophe
dc.date.accessioned
2021-06-03T12:59:18Z
dc.date.available
2017-06-09T17:29:07Z
dc.date.available
2021-06-03T12:58:37Z
dc.date.available
2021-06-03T12:59:18Z
dc.date.issued
2011-11
dc.identifier.issn
1467-5463
dc.identifier.issn
1477-4054
dc.identifier.other
10.1093/bib/bbr002
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/41897
dc.identifier.doi
10.3929/ethz-b-000041897
dc.description.abstract
With high-throughput technologies providing vast amounts of data, it has become more important to provide systematic, quality annotations. The Gene Ontology (GO) project is the largest resource for cataloguing gene function. Nonetheless, its use is not yet ubiquitous and is still fraught with pitfalls. In this review, we provide a short primer to the GO for bioinformaticians. We summarize important aspects of the structure of the ontology, describe sources and types of functional annotations, survey measures of GO annotation similarity, review typical uses of GO and discuss other important considerations pertaining to the use of GO in bioinformatics applications.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/2.5/
dc.subject
Gene ontology
en_US
dc.subject
Gene annotation
en_US
dc.subject
Semantic similarity
en_US
dc.subject
Gene function
en_US
dc.subject
Function prediction
en_US
dc.title
The what, where, how and why of gene ontology - a primer for bioinformaticians
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 2.5 Generic
dc.date.published
2011-02-17
ethz.journal.title
Briefings in Bioinformatics
ethz.journal.volume
12
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Brief. bioinform.
ethz.pages.start
723
en_US
ethz.pages.end
735
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-09T17:29:38Z
ethz.source
ECIT
ethz.identifier.importid
imp59364eb0322b290298
ethz.ecitpid
pub:69998
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T16:33:31Z
ethz.rosetta.lastUpdated
2024-02-02T13:51:26Z
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