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dc.contributor.author
Peduzzi, Neris
dc.contributor.author
Batliner, Martin
dc.contributor.author
Grass, Beate
dc.contributor.author
Buehler, Philipp K.
dc.contributor.author
Schmid Daners, Marianne
dc.contributor.author
Meboldt, Mirko
dc.contributor.author
Weiss, Markus
dc.date.accessioned
2020-09-23T05:16:14Z
dc.date.available
2020-06-25T11:09:32Z
dc.date.available
2020-06-26T11:40:03Z
dc.date.available
2020-09-23T05:16:14Z
dc.date.issued
2020-08
dc.identifier.other
10.1111/pan.13926
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/422648
dc.description.abstract
Objective The current study aimed to evaluate the extent of the slide‐stick phenomenon in differently designed infusion syringes at various infusion rates and filling positions. Methods Fluid delivery from three 50‐mL infusion syringe brands (BD; Codan; Fresenius) was investigated using a flow sensor at flow rates of 0.5, 1.0, or 5.0 mL h−1, with the syringes filled with either 10, 30, or 50 mL of distilled water. Two identical models (A/B) of the same infusion pump model were used. The effect of flow rate variations on the plasma concentration of a continuous epinephrine infusion in a 3 kg neonate receiving a continuous infusion of 0.1 μg kg min−1 epinephrine was studied using a pharmacokinetic simulation model. Results Considerable variations in calculated plasma epinephrine concentration were detected between flow rates of 5 and 0.5 or 1 mL h−1 for all syringe types and filling volumes. The median deviation of plasma concentration for the 5 mL h−1 flow rate varied depending on assembly from 1.3% (Codan) to 1.8% (Fresenius). This was more pronounced for lower flow rates, where at 1 mL h−1 the deviation varied from 3.3% (BD) to 4.8% (Fresenius) and at 0.5 mL h−1from 4.9% (BD) to 5.4% (Fresenius). Differences between filling volumes (within syringe type and flow rate) did not appear to have relevant influence on variations in calculated plasma epinephrine concentration. Conclusion Infusion set rate rather than syringe brand or filling volume was a major predictor for syringe stiction‐related amount of variation in the calculated plasma epinephrine concentration.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
Epinephrine
en_US
dc.subject
Infusion
en_US
dc.subject
Infusion pump
en_US
dc.subject
Irregularities
en_US
dc.subject
Syringe
en_US
dc.title
Flow irregularities from syringe infusion pumps caused by syringe stiction
en_US
dc.type
Journal Article
dc.date.published
2020-05-22
ethz.journal.title
Pediatric Anesthesia
ethz.journal.volume
30
en_US
ethz.journal.issue
8
en_US
ethz.pages.start
885
en_US
ethz.pages.end
891
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.pubmed
32443169
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02665 - Inst. f. Design, Mat. und Fabrikation::03943 - Meboldt, Mirko / Meboldt, Mirko
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02665 - Inst. f. Design, Mat. und Fabrikation::03943 - Meboldt, Mirko / Meboldt, Mirko
en_US
ethz.date.deposited
2020-06-25T11:09:42Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-09-23T05:16:33Z
ethz.rosetta.lastUpdated
2021-02-15T17:26:40Z
ethz.rosetta.versionExported
true
ethz.COinS
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