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dc.contributor.author
Wu, Dan
dc.contributor.author
Pujari-Palmer, Michael
dc.contributor.author
Bojan, Alicja
dc.contributor.author
Palmquist, Anders
dc.contributor.author
Procter, Philip
dc.contributor.author
Öhman-Mägi, Caroline
dc.contributor.author
Ferguson, Stephen J.
dc.contributor.author
Isaksson, Per
dc.contributor.author
Persson, Cecilia
dc.date.accessioned
2020-07-30T13:22:23Z
dc.date.available
2020-07-18T03:04:48Z
dc.date.available
2020-07-30T13:22:23Z
dc.date.issued
2020-10
dc.identifier.issn
1751-6161
dc.identifier.issn
1878-0180
dc.identifier.other
10.1016/j.jmbbm.2020.103897
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/426899
dc.identifier.doi
10.3929/ethz-b-000426899
dc.description.abstract
Augmentation materials, such as ceramic and polymeric bone cements, have been frequently used to improve the physical engagement of screws inserted into bone. While ceramic, degradable cements may ultimately improve fixation stability, reports regarding their effect on early fixation stability have been inconsistent. On the other hand, a newly developed degradable ceramic adhesive that can bond with tissues surrounding the screw, may improve the pullout performance, ensure early stability, and subsequent bony integration. The aim of this study was to investigate failure mechanisms of screw/trabecular bone constructs by comparing non-augmented screws with screws augmented with a calcium phosphate cement or an adhesive, i.e. a phosphoserine-modified calcium phosphate. Pullout tests were performed on screws inserted into trabecular cylinders extracted from human femoral bone. Continuous and stepwise pullout loading was applied with and without real-time imaging in a synchrotron radiation micro-computed tomograph, respectively. Statistical analysis that took the bone morphology into account confirmed that augmentation with the adhesive supported significantly higher pullout loads compared to cement-augmented, or non-augmented screws. However, the adhesive also allowed for a higher injection volume compared to the cement. In-situ imaging showed cracks in the vicinity of the screw threads in all groups, and detachment of the augmentation materials from the trabecular bone in the augmented specimens. Additional cracks at the periphery of the augmentation and the bone-material interfaces were only observed in the adhesive-augmented specimen, indicating a contribution of surface bonding to the pullout resistance. An adhesive that has potential for bonding with tissues, displayed superior pullout resistance, compared to a brushite cement, and may be a promising material for cementation or augmentation of implants.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Human trabecular bone
en_US
dc.subject
Pullout testing
en_US
dc.subject
Bone screws
en_US
dc.subject
Synchrotron radiation micro-computed tomography
en_US
dc.subject
Crack propagation
en_US
dc.subject
Calcium phosphate cement
en_US
dc.subject
Tissue adhesive
en_US
dc.subject
Phosphoserine modified cement
en_US
dc.title
The effect of two types of resorbable augmentation materials – a cement and an adhesive – on the screw pullout pullout resistance in human trabecular bone
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-06-25
ethz.journal.title
Journal of the Mechanical Behavior of Biomedical Materials
ethz.journal.volume
110
en_US
ethz.journal.abbreviated
J Mech Behav Biomed Mater
ethz.pages.start
103897
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03915 - Ferguson, Stephen / Ferguson, Stephen
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03915 - Ferguson, Stephen / Ferguson, Stephen
ethz.date.deposited
2020-07-18T03:04:54Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-07-30T13:22:36Z
ethz.rosetta.lastUpdated
2021-02-15T15:45:17Z
ethz.rosetta.versionExported
true
ethz.COinS
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