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dc.contributor.author
Schauenburg, Dominik
dc.contributor.author
Divandari, Mohammad
dc.contributor.author
Neumann, Kevin
dc.contributor.author
Spiegel, Christoph A.
dc.contributor.author
Hackett, Thomas
dc.contributor.author
Dzeng, Yi-Chung
dc.contributor.author
Spencer, Nicholas D.
dc.contributor.author
Bode, Jeffrey W.
dc.date.accessioned
2020-08-18T05:08:40Z
dc.date.available
2020-07-25T22:11:38Z
dc.date.available
2020-07-27T12:27:17Z
dc.date.available
2020-08-17T10:40:12Z
dc.date.available
2020-08-18T05:08:40Z
dc.date.issued
2020-08-17
dc.identifier.issn
1433-7851
dc.identifier.issn
1521-3773
dc.identifier.issn
0570-0833
dc.identifier.other
10.1002/anie.202006273
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/428439
dc.description.abstract
We report the synthesis of monomers for atom-transfer radical polymerization (ATRP) and a reversible addition-fragmentation chain transfer (RAFT) agent bearing trifluoroborate iminiums (TIMs), which are quantitatively converted into potassium acyltrifluoroborates (KATs) after polymerization. The resulting KAT-containing polymers are suitable for rapid amide-forming ligations for both post-polymerization modification and polymer conjugation. The polymer conjugation occurs rapidly, even under dilute (micromolar) aqueous conditions at ambient temperatures, thereby enabling the synthesis of a variety of linear and star-shaped block copolymers. In addition, we applied post-polymerization modification to the covalent linking of a photocaged cyclic antibiotic (gramicidin S) to the side chains of the KAT-containing copolymer. Cellular assays revealed that the polymer-antibiotic conjugate is biocompatible and provides efficient light-controlled release of the antibiotic on demand.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
Antibiotics
en_US
dc.subject
ATRP
en_US
dc.subject
KAT ligation
en_US
dc.subject
post-polymerization modification
en_US
dc.subject
RAFT
en_US
dc.title
Synthesis of Polymers Containing Potassium Acyltrifluoroborates (KATs) and Post-polymerization Ligation and Conjugation
en_US
dc.type
Journal Article
dc.date.published
2020-05-06
ethz.journal.title
Angewandte Chemie. International Edition
ethz.journal.volume
59
en_US
ethz.journal.issue
34
en_US
ethz.journal.abbreviated
Angew. Chem. Int. Ed.
ethz.pages.start
14656
en_US
ethz.pages.end
14663
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02160 - Dep. Materialwissenschaft / Dep. of Materials::02646 - Institut für Polymere / Institute of Polymers::03389 - Spencer, Nicholas (emeritus) / Spencer, Nicholas (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02160 - Dep. Materialwissenschaft / Dep. of Materials::02646 - Institut für Polymere / Institute of Polymers::03389 - Spencer, Nicholas (emeritus) / Spencer, Nicholas (emeritus)
ethz.relation.isOriginalFormOf
handle/20.500.11850/431369
ethz.date.deposited
2020-07-25T22:11:43Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-08-17T10:40:29Z
ethz.rosetta.lastUpdated
2021-02-15T16:12:09Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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