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dc.contributor.author
La Rosa, Chiara
dc.contributor.author
Cavallo, Francesca
dc.contributor.author
Pecora, Alessandra
dc.contributor.author
Chincarini, Matteo
dc.contributor.author
Ala, Ugo
dc.contributor.author
Faulkes, Chris G.
dc.contributor.author
Nacher, Juan
dc.contributor.author
Cozzi, Bruno
dc.contributor.author
Sherwood, Chet C.
dc.contributor.author
Amrein, Irmgard
dc.contributor.author
Bonfanti, Luca
dc.date.accessioned
2020-08-24T07:33:42Z
dc.date.available
2020-07-29T03:03:57Z
dc.date.available
2020-08-24T07:33:42Z
dc.date.issued
2020
dc.identifier.issn
2050-084X
dc.identifier.other
10.7554/eLife.55456
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/429004
dc.identifier.doi
10.3929/ethz-b-000429004
dc.description.abstract
The adult mammalian brain is mainly composed of mature neurons. A limited amount of stem cell-driven neurogenesis persists in postnatal life and is reduced in large-brained species. Another source of immature neurons in adult brains is cortical layer II. These cortical immature neurons (cINs) retain developmentally undifferentiated states in adulthood, though they are generated before birth. Here, the occurrence, distribution and cellular features of cINs were systematically studied in 12 diverse mammalian species spanning from small-lissencephalic to large-gyrencephalic brains. In spite of well-preserved morphological and molecular features, the distribution of cINs was highly heterogeneous, particularly in neocortex. While virtually absent in rodents, they are present in the entire neocortex of many other species and their linear density in cortical layer II generally increased with brain size. These findings suggest an evolutionary developmental mechanism for plasticity that varies among mammalian species, granting a reservoir of young cells for the cerebral cortex.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publications
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Phylogenetic variation in cortical layer II immature neuron reservoir of mammals
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-07-21
ethz.journal.title
eLife
ethz.journal.volume
9
en_US
ethz.pages.start
e55456
en_US
ethz.size
21 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-07-29T03:04:09Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-08-24T07:34:01Z
ethz.rosetta.lastUpdated
2022-03-29T02:57:43Z
ethz.rosetta.versionExported
true
ethz.COinS
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