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dc.contributor.author
Underwood, Mark A.
dc.contributor.author
Kalanetra, Karen M.
dc.contributor.author
Bokulich, Nicholas
dc.contributor.author
Mirmiran, Majid
dc.contributor.author
Barile, Daniela
dc.contributor.author
Tancredi, Daniel J.
dc.contributor.author
German, J. Bruce
dc.contributor.author
Lebrilla, Carlito B.
dc.contributor.author
Mills, David A.
dc.date.accessioned
2020-08-17T11:05:52Z
dc.date.available
2020-08-12T10:07:19Z
dc.date.available
2020-08-17T11:05:52Z
dc.date.issued
2014-03
dc.identifier.issn
0277-2116
dc.identifier.issn
1536-4801
dc.identifier.other
10.1097/MPG.0000000000000211
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/431167
dc.description.abstract
Objective: The aim of the study was to determine the impact of increasing doses of 2 prebiotic oligosaccharides and of an “all-human diet” on the intestinal microbiota of premature infants. Methods: Twelve premature infants receiving formula feedings were randomly assigned to receive either galacto-oligosaccharide (F+GOS) or a pooled concentrated donor human milk product containing human milk oligosaccharides (F+HMO) in increasing doses during a 5-week period. A second group of 15 premature infants received their mother's own milk fortified with either a concentrated donor human milk product (H+H) or a bovine powdered fortifier (H+B). Serial stool specimens from each infant were analyzed by terminal restriction fragment length polymorphism and quantitative polymerase chain reaction for bacterial composition. Results: All of the infants studied had relatively low levels of bifidobacteria and no measurable Lactobacilli. Infants from the F+GOS and F+HMO groups demonstrated an increase in relative numbers of Clostridia with increasing doses. Compared with the H+B group, the infants in the F+HMO and the H+H groups showed an unexpected trend toward an increase in γ-Proteobacteria over time/dose. Principal coordinate analyses and Shannon diversity scores were not significantly different among the 4 groups. Infants in the H+H group received more antibiotics during the study period than those in the other groups. Two of the infants receiving GOS developed feeding intolerance. Conclusions: None of the prebiotic interventions resulted in significant increases in bifidobacteria compared with baseline specimens or the H+B group; however, many of the infants did not receive the highest doses of GOS and HMO, and antibiotic use in the H+H group was high. © 2014 European Society.
en_US
dc.language.iso
en
en_US
dc.publisher
Lippincott Williams & Wilkins
en_US
dc.subject
All-human diet
en_US
dc.subject
Galacto-oligosaccharide
en_US
dc.subject
Human milk oligosaccharide
en_US
dc.subject
Late-onset sepsis
en_US
dc.subject
Necrotizing enterocolitis
en_US
dc.title
Prebiotic Oligosaccharides in Premature Infants
en_US
dc.type
Journal Article
ethz.journal.title
Journal of Pediatric Gastroenterology and Nutrition
ethz.journal.volume
58
en_US
ethz.journal.issue
3
en_US
ethz.journal.abbreviated
J Pediatr Gastroenterol Nutr
ethz.pages.start
352
en_US
ethz.pages.end
360
en_US
ethz.publication.place
Philadelphia, PA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::09714 - Bokulich, Nicholas / Bokulich, Nicholas
en_US
ethz.date.deposited
2020-08-12T10:07:27Z
ethz.source
BATCH
ethz.eth
no
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-08-17T11:06:14Z
ethz.rosetta.lastUpdated
2022-03-29T02:55:50Z
ethz.rosetta.versionExported
true
ethz.COinS
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