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dc.contributor.author
Chen, Qi
dc.contributor.author
Prior, Marguerite
dc.contributor.author
Dargusch, Richard
dc.contributor.author
Roberts, Amanda
dc.contributor.author
Riek, Roland
dc.contributor.author
Eichmann, Cédric
dc.contributor.author
Chiruta, Chandramouli
dc.contributor.author
Akaishi, Tatsuhiro
dc.contributor.author
Abe, Kazuho
dc.contributor.author
Maher, Pamela
dc.contributor.author
Schubert, David
dc.date.accessioned
2018-08-23T13:04:17Z
dc.date.available
2017-06-09T18:05:50Z
dc.date.available
2018-08-23T13:04:17Z
dc.date.issued
2011-12-14
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0027865
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/43152
dc.identifier.doi
10.3929/ethz-b-000043152
dc.description.abstract
Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. For Alzheimer's disease (AD), the focus is the amyloid beta peptide (Aß) that mediates familial Alzheimer's disease pathology. However, given that age is the greatest risk factor for AD, we explored an alternative drug discovery scheme that is based upon efficacy in multiple cell culture models of age-associated pathologies rather than exclusively amyloid metabolism. Using this approach, we identified an exceptionally potent, orally active, neurotrophic molecule that facilitates memory in normal rodents, and prevents the loss of synaptic proteins and cognitive decline in a transgenic AD mouse model.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer’s Disease
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
PLoS ONE
ethz.journal.volume
6
en_US
ethz.journal.issue
12
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e27865
en_US
ethz.size
17 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
006206116
ethz.publication.place
Lawrence, KS, USA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02515 - Laboratorium für Physikalische Chemie / Laboratory of Physical Chemistry::03782 - Riek, Roland / Riek, Roland
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02515 - Laboratorium für Physikalische Chemie / Laboratory of Physical Chemistry::03782 - Riek, Roland / Riek, Roland
ethz.date.deposited
2017-06-09T18:05:52Z
ethz.source
ECIT
ethz.identifier.importid
imp59364ec6728db61465
ethz.ecitpid
pub:71669
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T20:10:06Z
ethz.rosetta.lastUpdated
2018-11-07T23:40:56Z
ethz.rosetta.versionExported
true
ethz.COinS
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