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dc.contributor.author
Zielinski, Jana
dc.contributor.author
Ducray, Angélique D.
dc.contributor.author
Moeller, Anja M.
dc.contributor.author
Murbach, Manuel
dc.contributor.author
Kuster, Niels
dc.contributor.author
Mevissen, Meike
dc.date.accessioned
2020-08-18T11:48:57Z
dc.date.available
2020-08-16T12:16:53Z
dc.date.available
2020-08-18T11:48:57Z
dc.date.issued
2020-10
dc.identifier.issn
0887-2333
dc.identifier.other
10.1016/j.tiv.2020.104963
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/431588
dc.description.abstract
The use of body-worn wireless devices with different communication protocols and rapidly changing exposure scenarios is still multiplying and the need to identify possible health effects of radiofrequency electromagnetic field (RF-EMF) exposure with extremely low-frequency (ELF) modulation envelops. In this study, effects of ELF-modulated 935 MHz RF-EMF on apoptosis, autophagy, oxidative stress and electron exchange in N9 microglial and SH-SY5Y neuroblastoma cells were investigated. Cells were exposed at 4 W/kg or sham-exposed for 2 and 24 h. RF-EMF exposure of both cell types did not alter apoptosis, the number of living cells nor the apoptosis-inducing factor (AIF), irrespective of the exposure duration. RF-EMF exposure for 24, but not for 2 h, increased protein levels of the autophagy marker ATG5, whereas LC3B-I and II and pERK were not altered in both cell types and exposure times investigated. A transient increase in glutathione (GSH), but not hydrogen peroxide and cytochrome c oxidase was found only in SH-SY5Y cells, indicating that short-time RF-EMF at SAR levels accepted by today's safety guidelines might cause autophagy and oxidative stress with the effect being dependent on cell type and exposure duration. Further studies are needed to evaluate possible underlying mechanisms involved in pulse-modulated RF-EMF exposure. © Elsevier.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Radiofrequency electromagnetic fields
en_US
dc.subject
Neurodegeneration
en_US
dc.subject
Apoptosis
en_US
dc.subject
Oxidative stress
en_US
dc.subject
Autophagy
en_US
dc.subject
Brain cells
en_US
dc.title
Effects of pulse-modulated radiofrequency magnetic field (RF-EMF) exposure on apoptosis, autophagy, oxidative stress and electron chain transport function in human neuroblastoma and murine microglial cells
en_US
dc.type
Journal Article
dc.date.published
2020-08-08
ethz.journal.title
Toxicology in Vitro
ethz.journal.volume
68
en_US
ethz.journal.abbreviated
Toxicol. in vitro
ethz.pages.start
104963
en_US
ethz.size
10 p.
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-08-16T12:16:59Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-08-18T11:49:18Z
ethz.rosetta.lastUpdated
2021-02-15T16:34:08Z
ethz.rosetta.versionExported
true
ethz.COinS
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