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Date
2021-01Type
- Review Article
Citations
Cited 17 times in
Web of Science
Cited 18 times in
Scopus
ETH Bibliography
yes
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Abstract
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology. Show more
Publication status
publishedExternal links
Journal / series
Cellular and Molecular Life SciencesVolume
Pages / Article No.
Publisher
SpringerSubject
Hippo; Mechanisms; Regulation; Signaling pathways; TAZ; YAPOrganisational unit
03694 - Fussenegger, Martin / Fussenegger, Martin
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Show all metadata
Citations
Cited 17 times in
Web of Science
Cited 18 times in
Scopus
ETH Bibliography
yes
Altmetrics