Show simple item record

dc.contributor.author
Heng, Boon Chin
dc.contributor.author
Zhang, Xuehui
dc.contributor.author
Aubel, Dominique
dc.contributor.author
Bai, Yunyang
dc.contributor.author
Li, Xiaochan
dc.contributor.author
Wei, Yan
dc.contributor.author
Fussenegger, Martin
dc.contributor.author
Deng, Xuliang
dc.date.accessioned
2021-03-02T08:07:55Z
dc.date.available
2020-08-18T02:43:53Z
dc.date.available
2020-09-02T07:59:12Z
dc.date.available
2021-03-02T08:07:55Z
dc.date.issued
2021-01
dc.identifier.issn
1420-682X
dc.identifier.issn
1420-9071
dc.identifier.other
10.1007/s00018-020-03579-8
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/431791
dc.description.abstract
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.subject
Hippo
en_US
dc.subject
Mechanisms
en_US
dc.subject
Regulation
en_US
dc.subject
Signaling pathways
en_US
dc.subject
TAZ
en_US
dc.subject
YAP
en_US
dc.title
An overview of signaling pathways regulating YAP/TAZ activity
en_US
dc.type
Review Article
dc.date.published
2020-08-03
ethz.journal.title
Cellular and Molecular Life Sciences
ethz.journal.volume
78
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
Cell. Mol. Life Sci.
ethz.pages.start
497
en_US
ethz.pages.end
512
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cham
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03694 - Fussenegger, Martin / Fussenegger, Martin
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03694 - Fussenegger, Martin / Fussenegger, Martin
ethz.date.deposited
2020-08-18T02:43:58Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-03-02T08:08:04Z
ethz.rosetta.lastUpdated
2021-03-02T08:08:04Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=An%20overview%20of%20signaling%20pathways%20regulating%20YAP/TAZ%20activity&rft.jtitle=Cellular%20and%20Molecular%20Life%20Sciences&rft.date=2021-01&rft.volume=78&rft.issue=2&rft.spage=497&rft.epage=512&rft.issn=1420-682X&1420-9071&rft.au=Heng,%20Boon%20Chin&Zhang,%20Xuehui&Aubel,%20Dominique&Bai,%20Yunyang&Li,%20Xiaochan&rft.genre=article&rft_id=info:doi/10.1007/s00018-020-03579-8&
 Search print copy at ETH Library

Files in this item

FilesSizeFormatOpen in viewer

There are no files associated with this item.

Publication type

Show simple item record