Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function
dc.contributor.author
Babity, Samuel
dc.contributor.author
Polomska, Anna K.
dc.contributor.author
Couture, Frédéric
dc.contributor.author
Bonmarin, Mathias
dc.contributor.author
Fehr, Daniel
dc.contributor.author
Detmar, Michael
dc.contributor.author
Brambilla, Davide
dc.date.accessioned
2020-08-31T10:37:25Z
dc.date.available
2020-08-27T03:14:31Z
dc.date.available
2020-08-31T10:37:25Z
dc.date.issued
2020-11-10
dc.identifier.issn
0168-3659
dc.identifier.issn
1873-4995
dc.identifier.other
10.1016/j.jconrel.2020.08.017
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/432837
dc.description.abstract
The monitoring of lymphatic drainage is of great importance, particularly in the context of the early detection and diagnosis of several diseases. Existing methods of imaging and monitoring lymphatic drainage can be costly and require trained personnel, posing problems for at-home or point-of-care monitoring. Recently, an alternative approach has been proposed, consisting of using microneedles to deliver a near-infrared (NIR) fluorescent tattoo to the skin, which can be monitored with traditional laboratory-based fluorescence detectors. In this work, we present further development of this approach, using a specifically designed NIR-fluorescent probe and rational optimization of microneedle properties and the spatial location of the NIR dye within the microneedles. Moreover, we demonstrate that this method is compatible with a custom-made portable fluorescence measurement device and able to discriminate between drainage and lack of drainage in vivo in rats. © 2020 Elsevier B.V.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Microneedles
en_US
dc.subject
Monitoring
en_US
dc.subject
Tattoo
en_US
dc.subject
Diagnostics
en_US
dc.subject
Lymphatics
en_US
dc.title
Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function
en_US
dc.type
Journal Article
dc.date.published
2020-08-18
ethz.journal.title
Journal of Controlled Release
ethz.journal.volume
327
en_US
ethz.journal.abbreviated
J. control. release
ethz.pages.start
350
en_US
ethz.pages.end
359
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael (emeritus) / Detmar, Michael (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael (emeritus) / Detmar, Michael (emeritus)
ethz.date.deposited
2020-08-27T03:14:35Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-08-31T10:37:48Z
ethz.rosetta.lastUpdated
2024-02-02T11:56:48Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Rational%20design%20of%20a%20fluorescent%20microneedle%20tattoo%20for%20minimally%20invasive%20monitoring%20of%20lymphatic%20function&rft.jtitle=Journal%20of%20Controlled%20Release&rft.date=2020-11-10&rft.volume=327&rft.spage=350&rft.epage=359&rft.issn=0168-3659&1873-4995&rft.au=Babity,%20Samuel&Polomska,%20Anna%20K.&Couture,%20Fr%C3%A9d%C3%A9ric&Bonmarin,%20Mathias&Fehr,%20Daniel&rft.genre=article&rft_id=info:doi/10.1016/j.jconrel.2020.08.017&
Files in this item
Files | Size | Format | Open in viewer |
---|---|---|---|
There are no files associated with this item. |
Publication type
-
Journal Article [131350]