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dc.contributor.author
Lou, Phing-How
dc.contributor.author
Lucchinetti, Eliana
dc.contributor.author
Wawrzyniak, Paulina
dc.contributor.author
Morsy, Yasser
dc.contributor.author
Wawrzyniak, Marcin
dc.contributor.author
Scharl, Michael
dc.contributor.author
Krämer, Stefanie D.
dc.contributor.author
Rogler, Gerhard
dc.contributor.author
Hersberger, Martin
dc.contributor.author
Zaugg, Michael
dc.date.accessioned
2021-03-05T09:55:31Z
dc.date.available
2020-09-04T20:00:37Z
dc.date.available
2020-09-07T12:42:07Z
dc.date.available
2021-03-05T09:55:31Z
dc.date.issued
2021-03
dc.identifier.issn
1613-4125
dc.identifier.issn
1613-4133
dc.identifier.other
10.1002/mnfr.202000412
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/438565
dc.description.abstract
Scope The aim of this study is to test whether the choice of the lipid emulsion in total parenteral nutrition (TPN), that is, n‐3 fatty acid‐based Omegaven versus n‐6 fatty acid‐based Intralipid, determines inflammation in the liver, the incretin profile, and insulin resistance. Methods and results Jugular vein catheters (JVC) are placed in C57BL/6 mice and used for TPN for 7 days. Mice are randomized into a saline group (saline infusion with oral chow), an Intralipid group (IL‐TPN, no chow), an Omegaven group (OV‐TPN, no chow), or a chow only group (without JVC). Both TPN elicite higher abundance of lipopolysaccharide binding protein in the liver, but only IL‐TPN increases interleukin‐6 and interferon‐γ, while OV‐TPN reduces interleukin‐4, monocyte chemoattractant protein‐1, and interleukin‐1α. Insulin plasma concentrations are higher in both TPN, while glucagon and glucagon‐like peptide‐1 (GLP‐1) were higher in IL‐TPN. Gluconeogenesis is increased in IL‐TPN and the nuclear profile of key metabolic transcription factors shows a liver‐protective phenotype in OV‐TPN. OV‐TPN increases insulin sensitivity in the liver and skeletal muscle. Conclusion OV‐TPN as opposed to IL‐TPN mitigates inflammation in the liver and reduces the negative metabolic effects of hyperinsulinemia and hyperglucagonemia by “re‐sensitizing” the liver and skeletal muscle to insulin. © 2020 Wiley-VCH GmbH.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
Insulin
en_US
dc.subject
Liver
en_US
dc.subject
n-3 fatty acids
en_US
dc.subject
n-6 fatty acids
en_US
dc.subject
Total parenteral nutrition
en_US
dc.title
Choice of Lipid Emulsion Determines Inflammation of the Gut‐Liver Axis, Incretin Profile, and Insulin Signaling in a Murine Model of Total Parenteral Nutrition
en_US
dc.type
Journal Article
dc.date.published
2020-07-30
ethz.journal.title
Molecular Nutrition & Food Research
ethz.journal.volume
65
en_US
ethz.journal.issue
5
en_US
ethz.pages.start
2000412
en_US
ethz.size
15 p.
en_US
ethz.grant
Novel lipid nano-emulsions with superior biological actions: shifting paradigms in current parenteral nutrition
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
ethz.grant.agreementno
177225
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Sinergia
ethz.date.deposited
2020-09-04T20:00:59Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-03-05T09:55:43Z
ethz.rosetta.lastUpdated
2022-03-29T05:38:15Z
ethz.rosetta.versionExported
true
ethz.COinS
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