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dc.contributor.author
Rajendiran, Smrithi
dc.contributor.author
Smith-Berdan, Stephanie
dc.contributor.author
Kunz, Leo
dc.contributor.author
Risolino, Maurizio
dc.contributor.author
Selleri, Licia
dc.contributor.author
Schroeder, Timm
dc.contributor.author
Forsberg, E. Camilla
dc.date.accessioned
2020-09-10T09:55:54Z
dc.date.available
2020-09-04T20:17:36Z
dc.date.available
2020-09-10T09:55:54Z
dc.date.issued
2020-09
dc.identifier.issn
1066-5099
dc.identifier.issn
1066-6099
dc.identifier.issn
1549-4918
dc.identifier.other
10.1002/stem.3205
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/438629
dc.description.abstract
C-X-C motif chemokine ligand 12 (CXCL12; aka SDF1α) is a major regulator of a number of cellular systems, including hematopoiesis, where it influences hematopoietic cell trafficking, proliferation, and survival during homeostasis and upon stress and disease. A variety of constitutive, temporal, ubiquitous, and cell-specific loss-of-function models have documented the functional consequences on hematopoiesis upon deletion of Cxcl12. Here, in contrast to loss-of-function experiments, we implemented a gain-of-function approach by generating a doxycycline-inducible transgenic mouse model that enables spatial and temporal overexpression of Cxcl12. We demonstrated that ubiquitous CXCL12 overexpression led to an increase in multipotent progenitors in the bone marrow and spleen. The CXCL12+ mice displayed reduced reconstitution potential as either donors or recipients in transplantation experiments. Additionally, we discovered that Cxcl12 overexpression improved hematopoietic stem and progenitor cell mobilization into the blood, and conferred radioprotection by promoting quiescence. Thus, this new CXCL12+ mouse model provided new insights into major facets of hematopoiesis and serves as a versatile resource for studying CXCL12 function in a variety of contexts. © AlphaMed Press 2020
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
CXCL12 transgenic
en_US
dc.subject
hematopoiesis
en_US
dc.subject
hematopoietic stem cells
en_US
dc.subject
mobilization
en_US
dc.subject
radiation protection
en_US
dc.title
Ubiquitous overexpression of CXCL12 confers radiation protection and enhances mobilization of hematopoietic stem and progenitor cells
en_US
dc.type
Journal Article
dc.date.published
2020-05-22
ethz.journal.title
Stem Cells
ethz.journal.volume
38
en_US
ethz.journal.issue
9
en_US
ethz.journal.abbreviated
Stem cells
ethz.pages.start
1159
en_US
ethz.pages.end
1174
en_US
ethz.identifier.scopus
ethz.publication.place
Hoboken, NJ
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03992 - Schroeder, Timm / Schroeder, Timm
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03992 - Schroeder, Timm / Schroeder, Timm
ethz.date.deposited
2020-09-04T20:17:49Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-09-10T09:56:06Z
ethz.rosetta.lastUpdated
2021-02-15T17:08:01Z
ethz.rosetta.versionExported
true
ethz.COinS
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