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dc.contributor.author
Jörg, Elisa
dc.contributor.author
Sartori, Andrea M.
dc.contributor.author
Hofer, Anna-Sophie
dc.contributor.author
Baumann, Christian R.
dc.contributor.author
Kessler, Thomas M.
dc.date.accessioned
2020-09-10T07:13:19Z
dc.date.available
2020-09-06T12:50:46Z
dc.date.available
2020-09-10T07:13:19Z
dc.date.issued
2020-10
dc.identifier.issn
1353-8020
dc.identifier.other
10.1016/j.parkreldis.2020.08.032
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/438700
dc.description.abstract
Introduction While efficacy of deep brain stimulation for motor symptoms of neurological disorders is well accepted, its effects on the autonomic system remain controversial. We aimed to systematically assess all available evidence of deep brain stimulation effects on lower urinary tract function. Methods This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of Cochrane Central Register of Controlled Trials, Embase, Medline, Scopus, and Web of Science (last search July 12, 2019) and by screening of reference lists and reviews. Results After screening 577 articles, we included 29 studies enrolling a total of 1293 patients. Deep brain stimulation of the globus pallidus internus (GPi), pedunculopontine nucleus (PPN), and subthalamic nucleus (STN) had an inhibitory effect on detrusor function, while deep brain stimulation of the ventral intermediate nucleus of the thalamus (VIM) showed an excitatory effect. In the meta-analysis, deep brain stimulation of the STN led to a significant increase in maximum bladder capacity (mean difference 124 mL, 95% confidence interval 60–187 mL, p = 0.0001) but had no clinically relevant effects on other urodynamic parameters. Adverse events (reported in thirteen studies) were most commonly respiratory issues, postural instability, and dysphagia. Risk of bias and confounding was relatively low. Conclusions Deep brain stimulation does not impair lower urinary tract function and might even have beneficial effects. This needs to be considered in the deep brain stimulation decision-making process helping to encourage and to reassure prospective patients. © 2020 Elsevier Ltd.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Neuro-urology
en_US
dc.subject
Neurogenic lower urinary tract dysfunction
en_US
dc.subject
Deep brain stimulation
en_US
dc.subject
Systematic review
en_US
dc.subject
Meta-analysis
en_US
dc.title
Deep brain stimulation effects on lower urinary tract function: Systematic review and meta-analysis
en_US
dc.type
Review Article
dc.date.published
2020-08-26
ethz.journal.title
Parkinsonism & Related Disorders
ethz.journal.volume
79
en_US
ethz.journal.abbreviated
Parkinsonism Relat. Disord.
ethz.pages.start
65
en_US
ethz.pages.end
72
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-09-06T12:50:50Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-09-10T07:13:31Z
ethz.rosetta.lastUpdated
2021-02-15T17:07:06Z
ethz.rosetta.versionExported
true
ethz.COinS
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