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dc.contributor.author
Tanna, Tanmay
dc.contributor.author
Ramachanderan, Raghavendra
dc.contributor.author
Platt, Randall J.
dc.date.accessioned
2021-02-19T08:27:37Z
dc.date.available
2020-09-15T03:53:46Z
dc.date.available
2020-09-15T10:22:09Z
dc.date.available
2021-02-19T08:27:37Z
dc.date.issued
2021-02
dc.identifier.issn
1369-5274
dc.identifier.issn
1879-0364
dc.identifier.other
10.1016/j.mib.2020.07.014
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/440522
dc.identifier.doi
10.3929/ethz-b-000440522
dc.description.abstract
Advances in synthetic biology and microbiology have enabled the creation of engineered bacteria which can sense and report on intracellular and extracellular signals. When deployed in vivo these whole-cell bacterial biosensors can act as sentinels to monitor biomolecules of interest in human health and disease settings. This is particularly interesting in the context of the gut microbiota, which interacts extensively with the human host throughout time and transit of the gut and can be accessed from feces without requiring invasive collection. Leveraging rational engineering approaches for genetic circuits as well as an expanding catalog of disease-associated biomarkers, bacterial biosensors can act as non-invasive and easy-to-monitor reporters of the gut. Here, we summarize recent engineering approaches applied in vivo in animal models and then highlight promising technologies for designing the next generation of bacterial biosensors.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Engineered bacteria to report gut function: technologies and implementation
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2020-08-19
ethz.journal.title
Current Opinion in Microbiology
ethz.journal.volume
59
en_US
ethz.journal.abbreviated
Curr. opin. microbiol.
ethz.pages.start
24
en_US
ethz.pages.end
33
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Reconstructing cellular histories with transcriptional recording
en_US
ethz.grant
Identification of convergent molecular pathways in autism spectrum disorder by in utero genome editing and transcriptional profiling of cortical projection neuron subtypes
en_US
ethz.grant
In vivo interrogation of cellular essential genes with CRISPR-Cas9
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Kidlington
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::09580 - Platt, Randall / Platt, Randall
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::09580 - Platt, Randall / Platt, Randall
ethz.grant.agreementno
851021
ethz.grant.agreementno
175830
ethz.grant.agreementno
ETH-27 18-2
ethz.grant.fundername
EC
ethz.grant.fundername
SNF
ethz.grant.fundername
ETHZ
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100003006
ethz.grant.program
H2020
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.grant.program
ETH Grants
ethz.date.deposited
2020-09-15T03:53:59Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-09-15T10:22:24Z
ethz.rosetta.lastUpdated
2021-02-15T17:15:01Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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