Intrinsic noise alters the frequency spectrum of mesoscopic oscillatory chemical reaction systems

Open access
Date
2011-11-11Type
- Journal Article
Abstract
Mesoscopic oscillatory reaction systems, for example in cell biology, can exhibit stochastic oscillations in the form of cyclic random walks even if the corresponding macroscopic system does not oscillate. We study how the intrinsic noise from molecular discreteness influences the frequency spectrum of mesoscopic oscillators using as a model system a cascade of coupled Brusselators away from the Hopf bifurcation. The results show that the spectrum of an oscillator depends on the level of noise. In particular, the peak frequency of the oscillator is reduced by increasing noise, and the bandwidth increased. Along a cascade of coupled oscillators, the peak frequency is further reduced with every stage and also the bandwidth is reduced. These effects can help understand the role of noise in chemical oscillators and provide fingerprints for more reliable parameter identification and volume measurement from experimental spectra. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000044070Publication status
publishedExternal links
Journal / series
Scientific ReportsVolume
Pages / Article No.
Publisher
NatureSubject
Biophysics; Biophysical chemistry; Chemical physicsOrganisational unit
03749 - Sbalzarini, Ivo F.
More
Show all metadata