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dc.contributor.author
Ramaswamy, Rajesh
dc.contributor.author
Sbalzarini, Ivo F.
dc.date.accessioned
2018-09-11T10:33:54Z
dc.date.available
2017-06-09T18:24:21Z
dc.date.available
2018-09-11T10:33:54Z
dc.date.issued
2011-11-11
dc.identifier.other
10.1038/srep00154
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/44070
dc.identifier.doi
10.3929/ethz-b-000044070
dc.description.abstract
Mesoscopic oscillatory reaction systems, for example in cell biology, can exhibit stochastic oscillations in the form of cyclic random walks even if the corresponding macroscopic system does not oscillate. We study how the intrinsic noise from molecular discreteness influences the frequency spectrum of mesoscopic oscillators using as a model system a cascade of coupled Brusselators away from the Hopf bifurcation. The results show that the spectrum of an oscillator depends on the level of noise. In particular, the peak frequency of the oscillator is reduced by increasing noise, and the bandwidth increased. Along a cascade of coupled oscillators, the peak frequency is further reduced with every stage and also the bandwidth is reduced. These effects can help understand the role of noise in chemical oscillators and provide fingerprints for more reliable parameter identification and volume measurement from experimental spectra.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject
Biophysics
en_US
dc.subject
Biophysical chemistry
en_US
dc.subject
Chemical physics
en_US
dc.title
Intrinsic noise alters the frequency spectrum of mesoscopic oscillatory chemical reaction systems
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
ethz.journal.title
Scientific Reports
ethz.journal.volume
1
en_US
ethz.pages.start
154
en_US
ethz.size
7 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
006751867
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
03749 - Sbalzarini, Ivo F.
en_US
ethz.leitzahl.certified
03749 - Sbalzarini, Ivo F.
ethz.date.deposited
2017-06-09T18:24:44Z
ethz.source
ECIT
ethz.identifier.importid
imp59364ed4b9c8196576
ethz.ecitpid
pub:72845
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T07:11:56Z
ethz.rosetta.lastUpdated
2019-01-02T13:52:20Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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