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dc.contributor.author
Fioretta, Emanuela S.
dc.contributor.author
Motta, Sarah E.
dc.contributor.author
Lintas, Valentina
dc.contributor.author
Loerakker, Sandra
dc.contributor.author
Parker, Kevin K.
dc.contributor.author
Baaijens, Frank P. T.
dc.contributor.author
Falk, Volkmar
dc.contributor.author
Hoerstrup, Simon P.
dc.contributor.author
Emmert, Maximilian Y.
dc.date.accessioned
2020-09-25T12:50:08Z
dc.date.available
2020-09-23T02:43:07Z
dc.date.available
2020-09-25T12:50:08Z
dc.date.issued
2020
dc.identifier.other
10.1038/s41569-020-0422-8
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/442004
dc.description.abstract
Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve repair or replacement has been the standard of care for patients with valvular heart disease for many decades, but transcatheter heart valve therapy has revolutionized the field in the past 15 years. However, despite the tremendous technical evolution of transcatheter heart valves, to date, the clinically available heart valve prostheses for surgical and transcatheter replacement have considerable limitations. The design of next-generation tissue-engineered heart valves (TEHVs) with repair, remodelling and regenerative capacity can address these limitations, and TEHVs could become a promising therapeutic alternative for patients with valvular disease. In this Review, we present a comprehensive overview of current clinically adopted heart valve replacement options, with a focus on transcatheter prostheses. We discuss the various concepts of heart valve tissue engineering underlying the design of next-generation TEHVs, focusing on off-the-shelf technologies. We also summarize the latest preclinical and clinical evidence for the use of these TEHVs and describe the current scientific, regulatory and clinical challenges associated with the safe and broad clinical translation of this technology. © 2020 Springer Nature Limited.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.title
Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity
en_US
dc.type
Review Article
dc.date.published
2020-09-09
ethz.journal.title
Nature Reviews Cardiology
ethz.identifier.wos
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-09-23T02:43:12Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.date.embargoend
2020-09-09
ethz.rosetta.exportRequired
true
ethz.COinS
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