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dc.contributor.author
Ray, Ankita
dc.contributor.author
Liosi, Korinne
dc.contributor.author
Ramakrishna, Shivaprakash N.
dc.contributor.author
Spencer, Nicholas D.
dc.contributor.author
Kuzuya, Akinori
dc.contributor.author
Yamakoshi, Yoko
dc.date.accessioned
2020-09-28T07:01:18Z
dc.date.available
2020-09-26T19:49:22Z
dc.date.available
2020-09-28T07:01:18Z
dc.date.issued
2020-09-17
dc.identifier.issn
1948-7185
dc.identifier.other
10.1021/acs.jpclett.0c02257
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/442884
dc.description.abstract
Light-induced oxidative damage of DNA by 1O2 generated from photoexcited C60 was observed at the single-molecule level by atomic force microscopy (AFM) imaging. Two types of DNA origami with uniform morphologies were immobilized on a mica surface and used as DNA substrates. Upon visible light irradiation (528 nm) in the presence of a C60 aqueous solution, the morphology changes of DNA origami substrates were observed by time-lapse AFM imaging at the single-molecule level by tracking a discrete DNA molecule. The origami showed nicked and flattened morphologies with relaxed features caused by the covalent cleavage of the DNA strands. The involvement of 1O2 in the on-surface DNA damage was clearly confirmed by AFM experiments in the presence of a 1O2 quencher and ESR measurements with a spin-trapping agent for 1O2. This study is the first example of single-molecule observation of oxidative damage of DNA by AFM with corresponding morphology changes in a photocontrolled and time-dependent manner by 1O2 generated catalytically from photoexcited C60. © 2020 American Chemical Society.
en_US
dc.language.iso
en
en_US
dc.publisher
American Chemical Society
en_US
dc.title
Single-Molecule AFM Study of DNA Damage by 1O2 Generated from Photoexcited C60
en_US
dc.type
Journal Article
dc.date.published
2020-08-24
ethz.journal.title
The Journal of Physical Chemistry Letters
ethz.journal.volume
11
en_US
ethz.journal.issue
18
en_US
ethz.journal.abbreviated
J. phys. chem. lett.
ethz.pages.start
7819
en_US
ethz.pages.end
7826
en_US
ethz.grant
Synthesis and Study of Photoexcited Fullerenes
en_US
ethz.grant
Porphyrin-based imaging probe for the detection of oncogene promoter quadruplex DNA
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02160 - Dep. Materialwissenschaft / Dep. of Materials::02646 - Institut für Polymere / Institute of Polymers::03389 - Spencer, Nicholas (emeritus) / Spencer, Nicholas (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02160 - Dep. Materialwissenschaft / Dep. of Materials::02646 - Institut für Polymere / Institute of Polymers::03389 - Spencer, Nicholas (emeritus) / Spencer, Nicholas (emeritus)
ethz.grant.agreementno
156097
ethz.grant.agreementno
183660
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Mathematik, Natur- und Ingenieurwissenschaften (Abteilung II)
ethz.grant.program
Strategic Japanese-Swiss Science and Technology Program (SJSSTP)
ethz.date.deposited
2020-09-26T19:49:30Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-09-28T07:01:29Z
ethz.rosetta.lastUpdated
2020-09-28T07:01:29Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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