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dc.contributor.author
Goudu, Sandhya R.
dc.contributor.author
Yasa, Immihan C.
dc.contributor.author
Hu, Xinghao
dc.contributor.author
Ceylan, Hakan
dc.contributor.author
Hu, Wenqi
dc.contributor.author
Sitti, Metin
dc.date.accessioned
2020-09-29T12:12:08Z
dc.date.available
2020-09-29T03:27:27Z
dc.date.available
2020-09-29T12:12:08Z
dc.date.issued
2020
dc.identifier.other
10.1002/adfm.202004975
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/443284
dc.description.abstract
Small-scale magnetic soft-bodied robots based on biocompatible and biodegradable materials are essential for their potential high-impact minimally invasive medical applications inside the human body. Therefore, a strategy for fully biodegradable untethered soft millirobots with encoded 3D magnetic anisotropy for their static or dynamic shape programming is presented. Such a robot body is comprised of a porcine extracellular matrix-derived collagen-based hydrogel network with embedded superparamagnetic iron oxide nanoparticles (SPIONs). 3D magnetization programming inside the hydrogel body is achieved by directionally self-assembled SPION chains using an external permanent magnet. As a proof-of-concept demonstration, a hydrogel milli-gripper that can undergo flexible and reversible shape deformations inside glycerol and biologically relevant liquid media is presented. The gripper can perform cargo grabbing, transportation by rolling, and release by controlling magnetic field inputs. These milli-grippers can be completely degraded by the matrix metalloproteinase-2 enzyme in physiologically relevant concentrations. Furthermore, biocompatibility tests using human umbilical cord vein endothelial cells with the degradation products of the grippers demonstrate no acute toxicity. The approach offers a facile fabrication strategy for designing biocompatible and biodegradable soft robots using nanocomposite materials with programmable 3D magnetic anisotropy toward future medical applications.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
biocompatible
en_US
dc.subject
biodegradable
en_US
dc.subject
medical devices
en_US
dc.subject
millirobot
en_US
dc.subject
soft robot
en_US
dc.title
Biodegradable Untethered Magnetic Hydrogel Milli-Grippers
en_US
dc.type
Journal Article
dc.date.published
2020-09-15
ethz.journal.title
Advanced Functional Materials
ethz.size
9 p.
en_US
ethz.identifier.wos
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-09-29T03:27:32Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.exportRequired
true
ethz.COinS
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