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dc.contributor.author
Bostanci, Nagihan
dc.contributor.author
Silbereisen, Angelika
dc.contributor.author
Bao, Kai
dc.contributor.author
Grossmann, Jonas
dc.contributor.author
Nanni, Paolo
dc.contributor.author
Fernandez, Claudia
dc.contributor.author
Nascimento, Gustavo G.
dc.contributor.author
Belibasakis, Georgios N.
dc.contributor.author
Lopez, Rodrigo
dc.date.accessioned
2020-11-13T09:10:51Z
dc.date.available
2020-10-01T07:15:14Z
dc.date.available
2020-10-02T05:55:55Z
dc.date.available
2020-11-13T09:10:51Z
dc.date.issued
2020-11
dc.identifier.issn
0303-6979
dc.identifier.issn
1600-051X
dc.identifier.other
10.1111/jcpe.13358
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/443801
dc.identifier.doi
10.3929/ethz-b-000443801
dc.description.abstract
Aim This study aimed to characterize the salivary proteome during the induction and resolution of gingival inflammation in the course of human experimental gingivitis (EG), and to cluster the proteomic profiles based on the clinically defined "slow" and "fast" response patterns. Materials and Methods A total of 50 unstimulated whole saliva were obtained from the EG model which was induced over 21 days (days 0, 7, 14 and 21), followed by a two-week resolution phase (day 35). Label-free quantitative proteomics using liquid chromatography-tandem mass spectrometry was applied. Regulated proteins were subject to Gene Ontology enrichment analysis. Results A total of 804 human proteins were quantified by >= 2 peptides. Principal component analysis depicted significant differences between "fast" and "slow" responders. Despite gingival and plaque scores being similar at baseline among the two groups, "fast" responders presented with 48 proteins that were at > 4-fold higher levels than "slow" responders. These up-regulated proteins showed enrichment in "antigen presentation" and "proteolysis." Conclusions Together, these findings highlight the utility of integrative systems-level quantitative proteomic approaches to unravel the molecular basis of "salivary proteotypes" associated with gingivitis dubbed as "fast" and "slow" responders. Hence, these differential responses may help prognosticate individual susceptibility to gingival inflammation.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
biomarkers
en_US
dc.subject
experimental gingivitis
en_US
dc.subject
proteomics
en_US
dc.subject
proteomics
en_US
dc.subject
saliva
en_US
dc.subject
salivary proteotypes
en_US
dc.title
Salivary proteotypes of gingivitis tolerance and resilience
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2020-08-10
ethz.journal.title
Journal of Clinical Periodontology
ethz.journal.volume
47
en_US
ethz.journal.issue
11
en_US
ethz.journal.abbreviated
J. Clin. Periodontol.
ethz.pages.start
1304
en_US
ethz.pages.end
1316
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.date.deposited
2020-10-01T07:15:23Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-11-13T09:11:03Z
ethz.rosetta.lastUpdated
2021-02-15T20:44:52Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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