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dc.contributor.author
Do, Cao-Tri
dc.contributor.author
Manjaly, Zina-Mary
dc.contributor.author
Heinzle, Jakob
dc.contributor.author
Schöbi, Dario
dc.contributor.author
Kasper, Lars
dc.contributor.author
Pruessmann, Klaas P.
dc.contributor.author
Stephan, Klaas
dc.contributor.author
Frässle, Stefan
dc.date.accessioned
2021-03-05T08:40:36Z
dc.date.available
2020-10-07T14:17:58Z
dc.date.available
2020-10-08T08:59:45Z
dc.date.available
2021-03-05T08:40:36Z
dc.date.issued
2021-02
dc.identifier.issn
0953-816X
dc.identifier.issn
1460-9568
dc.identifier.other
10.1111/ejn.14970
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/444944
dc.description.abstract
Aspirin is considered a potential confound for functional magnetic resonance imaging (fMRI) studies. This is because aspirin affects the synthesis of prostaglandin, a vasoactive mediator centrally involved in neurovascular coupling, a process underlying blood oxygenated level dependent (BOLD) responses. Aspirin‐induced changes in BOLD signal are a potential confound for fMRI studies of at‐risk individuals or patients (e.g. with cardiovascular conditions or stroke) who receive low‐dose aspirin prophylactically and are compared to healthy controls without aspirin. To examine the severity of this potential confound, we combined high field (7 Tesla) MRI during a simple hand movement task with a biophysically informed hemodynamic model. We compared elderly individuals receiving aspirin for primary or secondary prophylactic purposes versus age‐matched volunteers without aspirin medication, testing for putative differences in BOLD responses. Specifically, we fitted hemodynamic models to BOLD responses from 14 regions activated by the task and examined whether model parameter estimates were significantly altered by aspirin. While our analyses indicate that hemodynamics differed across regions, consistent with the known regional variability of BOLD responses, we neither found a significant main effect of aspirin (i.e., an average effect across brain regions) nor an expected drug × region interaction. While our sample size is not sufficiently large to rule out small‐to‐medium global effects of aspirin, we had adequate statistical power for detecting the expected interaction. Altogether, our analysis suggests that patients with cardiovascular risk receiving low‐dose aspirin for primary or secondary prophylactic purposes do not show strongly altered BOLD signals when compared to healthy controls without aspirin. © 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
Aspirin
en_US
dc.subject
Dynamic causal modeling
en_US
dc.subject
fMRI
en_US
dc.subject
Generative modeling
en_US
dc.subject
Neurovascular coupling
en_US
dc.title
Hemodynamic modeling of long‐term aspirin effects on blood oxygenated level dependent responses at 7 Tesla in patients at cardiovascular risk
en_US
dc.type
Journal Article
dc.date.published
2020-09-16
ethz.journal.title
European Journal of Neuroscience
ethz.journal.volume
53
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Eur. j. neurosci.
ethz.pages.start
1262
en_US
ethz.pages.end
1278
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Hoboken, NJ
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03628 - Prüssmann, Klaas P. / Prüssmann, Klaas P.
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03628 - Prüssmann, Klaas P. / Prüssmann, Klaas P.
ethz.date.deposited
2020-10-07T14:18:03Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-03-05T08:40:47Z
ethz.rosetta.lastUpdated
2021-03-05T08:40:47Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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