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dc.contributor.author
Michoud, Frédéric
dc.contributor.author
Seehus, Corey
dc.contributor.author
Schönle, Philipp
dc.contributor.author
Brun, Noé
dc.contributor.author
Taub, Daniel
dc.contributor.author
Zhang, Zihe
dc.contributor.author
Jain, Aakanksha
dc.contributor.author
Furfaro, Ivan
dc.contributor.author
Akouissi, Outman
dc.contributor.author
Moon, Rachel
dc.contributor.author
Meier, Pascale
dc.contributor.author
Galan, Katia
dc.contributor.author
Doyle, Benjamin
dc.contributor.author
Tetreault, Michael
dc.contributor.author
Talbot, Sébastien
dc.contributor.author
Browne, Liam E.
dc.contributor.author
Huang, Qiuting
dc.contributor.author
Woolf, Clifford J.
dc.contributor.author
Lacour, Stéphanie P.
dc.date.accessioned
2021-03-05T14:18:38Z
dc.date.available
2020-10-07T14:19:03Z
dc.date.available
2020-10-08T11:02:20Z
dc.date.available
2021-01-27T06:26:18Z
dc.date.available
2021-03-05T14:18:38Z
dc.date.issued
2021-02
dc.identifier.issn
1546-1696
dc.identifier.issn
1087-0156
dc.identifier.other
10.1038/s41587-020-0673-2
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/444951
dc.description.abstract
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation1,2, but whether nociceptors also interact with the immune system remains poorly understood. Here we report a neurotechnology for selective epineural optogenetic neuromodulation of nociceptors and demonstrate that nociceptor activation drives both protective pain behavior and inflammation. The wireless optoelectronic system consists of sub-millimeter-scale light-emitting diodes embedded in a soft, circumneural sciatic nerve implant, powered and driven by a miniaturized head-mounted control unit. Photostimulation of axons in freely moving mice that express channelrhodopsin only in nociceptors resulted in behaviors characteristic of pain, reflecting orthodromic input to the spinal cord. It also led to immune reactions in the skin in the absence of inflammation and potentiation of established inflammation, a consequence of the antidromic activation of nociceptor peripheral terminals. These results reveal a link between nociceptors and immune cells, which might have implications for the treatment of inflammation.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.subject
Biomedical engineering
en_US
dc.subject
Neuroimmunology
en_US
dc.title
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
en_US
dc.type
Journal Article
dc.date.published
2020-09-21
ethz.journal.title
Nature Biotechnology
ethz.journal.volume
39
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
Nat Biotechnol
ethz.pages.start
179
en_US
ethz.pages.end
185
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02636 - Institut für Integrierte Systeme / Integrated Systems Laboratory::03380 - Huang, Qiuting (emeritus) / Huang, Qiuting (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02636 - Institut für Integrierte Systeme / Integrated Systems Laboratory::03380 - Huang, Qiuting (emeritus) / Huang, Qiuting (emeritus)
ethz.date.deposited
2020-10-07T14:19:08Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2021-03-05T14:18:50Z
ethz.rosetta.lastUpdated
2022-03-29T05:38:52Z
ethz.rosetta.versionExported
true
ethz.COinS
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