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dc.contributor.author
Muri, Jonathan
dc.contributor.author
Thut, Helen
dc.contributor.author
Kopf, Manfred
dc.date.accessioned
2020-10-13T15:10:51Z
dc.date.available
2020-10-10T02:43:35Z
dc.date.available
2020-10-13T15:10:51Z
dc.date.issued
2020
dc.identifier.other
10.1002/eji.202048851
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/445387
dc.description.abstract
Thioredoxin-1 (Trx1) is a vital component for cellular redox homeostasis. In T cells, Trx1 donates electrons for the de novo synthesis of deoxyribonucleotides to allow rapid cell proliferation. The Trx-interacting protein (Txnip) binds to the reduced Trx1 and inhibits its activity. However, the role of Txnip in adaptive immunity in vivo is unknown. Here, we show that absence of Txnip increased proliferation of effector T cells and GC B-cell responses in response to lymphocytic choriomeningitis virus and Q beta virus-like particles, respectively, but did not affect development and homeostasis of T and B cells. While downregulation of Txnip and concomitant upregulation of Trx1 is critical for rapid T-cell expansion upon viral infection, re-expression of Txnip and consequently inhibition of Trx1 is important to restrain late T-cell expansion. Importantly, we demonstrated that T-cell receptor (TCR) engagement but not CD28 costimulation is critically required for Txnip downregulation. Thus, this study further uncovers positive and negative control of lymphocyte proliferation by the Trx1 system.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
Germinal center (GC) B cells
en_US
dc.subject
Immune responses
en_US
dc.subject
T-cell proliferation
en_US
dc.subject
Thioredoxin-1 (Trx1) system
en_US
dc.subject
Thioredoxin-interacting protein (Txnip)
en_US
dc.title
The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion
en_US
dc.type
Journal Article
dc.date.published
2020-09-09
ethz.journal.title
European journal of immunology
ethz.size
10 p.
en_US
ethz.identifier.wos
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-10-10T02:43:45Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.exportRequired
true
ethz.COinS
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