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dc.contributor.author
Stoffel, Nicole U.
dc.contributor.author
von Siebenthal, Hanna K.
dc.contributor.author
Moretti, Diego
dc.contributor.author
Zimmermann, Michael B.
dc.date.accessioned
2020-10-22T17:09:22Z
dc.date.available
2020-10-16T03:40:37Z
dc.date.available
2020-10-22T17:09:22Z
dc.date.issued
2020-10
dc.identifier.other
10.1016/j.mam.2020.100865
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/446224
dc.identifier.doi
10.3929/ethz-b-000446224
dc.description.abstract
Iron deficiency and iron deficiency anemia (IDA) are major public health problems worldwide, especially in young women. Oral iron supplementation can be an effective strategy to treat and prevent IDA, but guidelines vary. Some experts recommend doses of 150–200 mg elemental iron per day, with the dose split through the day. However, recent studies suggest this may not be an optimal regimen. The fraction of iron absorbed from high doses of oral iron is low, and unabsorbed iron can cause gut irritation, inflammation and dysbiosis, and these reduce compliance. In recent studies using serum hepcidin profiles and stable iron isotopes to quantify iron absorption in young women, we have shown that: (a) oral iron doses ≥60 mg in iron-deficient women, and doses ≥100 mg in women with IDA, stimulate an acute increase in hepcidin that persists 24 h after the dose, but subsides by 48 h; (b) therefore, to maximize fractional iron absorption, oral doses ≥60 mg should be given on alternate days; (c) the circadian increase in plasma hepcidin is augmented by a morning iron dose; therefore, iron doses should not be given in the afternoon or evening after a morning dose. If rate of Hb response is important, a pooled analysis of our data done for this review indicates that total iron absorption is also higher if twice the target daily iron dose is given on alternate days. In summary, these studies suggest changing from daily to alternate-day schedules and from divided to morning single doses increases iron absorption and may reduce side effects. Thus, providing morning doses of 60–120 mg iron as a ferrous salt given with ascorbic acid on alternate days may be an optimal oral dosing regimen for women with iron-deficiency and mild IDA.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Iron
en_US
dc.subject
Deficiency
en_US
dc.subject
Anemia
en_US
dc.subject
Women
en_US
dc.subject
Supplementation
en_US
dc.subject
Hepcidin
en_US
dc.subject
Side effects
en_US
dc.subject
Absorption
en_US
dc.subject
Dose
en_US
dc.subject
Regimen
en_US
dc.title
Oral iron supplementation in iron-deficient women: How much and how often?
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2020-07-07
ethz.journal.title
Molecular Aspects of Medicine
ethz.journal.volume
75
en_US
ethz.pages.start
100865
en_US
ethz.size
9 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03957 - Zimmermann, Michael Bruce (emeritus) / Zimmermann, Michael Bruce (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03957 - Zimmermann, Michael Bruce (emeritus) / Zimmermann, Michael Bruce (emeritus)
ethz.date.deposited
2020-10-16T03:40:43Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-10-22T17:09:37Z
ethz.rosetta.lastUpdated
2023-02-06T20:35:58Z
ethz.rosetta.versionExported
true
ethz.COinS
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