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dc.contributor.author
Zeimpekis, Konstantinos G.
dc.contributor.supervisor
Prüssmann, Klaas P.
dc.contributor.supervisor
Rasche, Volker
dc.contributor.supervisor
Stolzmann, Paul
dc.date.accessioned
2020-10-16T12:52:28Z
dc.date.available
2020-10-16T12:27:10Z
dc.date.available
2020-10-16T12:52:28Z
dc.date.issued
2020-09
dc.identifier.uri
http://hdl.handle.net/20.500.11850/446370
dc.identifier.doi
10.3929/ethz-b-000446370
dc.description.abstract
It is Zeu’s anathema on Magnetic Resonance Imaging (MRI) of the lung that we should agonize between the Scylla of the rapid decaying magnetization signal and the Harybdis of respiratory motion and long acquisition times. This thesis deals with the clinical issues of the aforementioned problems. The main core of the work is to optimize the 3D Ultrashort echo-time (UTE) Cones sequence for lung imaging in terms of image quality, respiratiory motion and acquisition times, primarily for visualization and quantification of the lung parenchyma. Especially for the lung, the conventional MRI sequences cannot capture signal from the parenchyma and in general the images are not of sufficient diagnostic value. 3D UTE Cones, is tested clinically on pediatric patients referred for lung lesions and compared to the routine sequence -Periodically Rotated Overlapping Parallel Lines with Enhanced Reconstruction (PROPELLER). Cones is able to capture the lung density based on the patient’s age and additionally sets itself as a proper sequence for lung Positron Emission Tomography (PET) attenuation correction (AC) in PET/MR scans. Another two chapters regard retrospective gating of the lung motion based on the extracted DC self-navigator from the central k-space and description of the development of conjugate gradient (CG)-SENSE reconstruction for the non-cartesion Cones parallel imaging using sensitivity maps generated by the image data for fast MR lung imaging. Supplementary, one publication regards the clinical comparison of the image quality between time-of-flight (TOF)-PET/CT and TOF-PET/MRI in relation to various acquisition times proving the superior PET sensitivity of the PET/MRI.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
ETH Zurich
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.subject
MRI (magnetic resonance imaging)
en_US
dc.subject
MRI
en_US
dc.subject
Medical imaging
en_US
dc.subject
Lung
en_US
dc.subject
LUNG DIAGNOSTICS (MEDICINE)
en_US
dc.subject
Ultrashort echo-time MRI
en_US
dc.subject
Zero echo time
en_US
dc.title
MRI of the lung parenchyma - technical advances and clinical evaluation
en_US
dc.type
Doctoral Thesis
dc.rights.license
In Copyright - Non-Commercial Use Permitted
dc.date.published
2020-10-16
ethz.size
148 p.
en_US
ethz.code.ddc
DDC - DDC::6 - Technology, medicine and applied sciences::621.3 - Electric engineering
en_US
ethz.code.ddc
DDC - DDC::6 - Technology, medicine and applied sciences::610 - Medical sciences, medicine
en_US
ethz.code.ddc
DDC - DDC::5 - Science::530 - Physics
en_US
ethz.identifier.diss
26753
en_US
ethz.publication.place
Zurich
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03628 - Prüssmann, Klaas P. / Prüssmann, Klaas P.
en_US
ethz.date.deposited
2020-10-16T12:27:20Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-10-16T12:52:40Z
ethz.rosetta.lastUpdated
2021-02-15T18:25:51Z
ethz.rosetta.versionExported
true
ethz.COinS
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