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dc.contributor.author
Schwarzenberg, Peter
dc.contributor.author
Klein, Karina
dc.contributor.author
Ferguson, Stephen J.
dc.contributor.author
von Rechenberg, Brigitte
dc.contributor.author
Darwiche, Salim
dc.contributor.author
Dailey, Hannah L.
dc.date.accessioned
2020-10-19T12:27:53Z
dc.date.available
2020-10-17T02:41:37Z
dc.date.available
2020-10-19T12:27:53Z
dc.date.issued
2020
dc.identifier.issn
1749-799X
dc.identifier.other
10.1002/jor.24866
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/446439
dc.description.abstract
Finite element analysis with models derived from computed tomography (CT) scans is potentially powerful as a translational research tool because it can achieve what animal studies and cadaver biomechanics cannot-low-risk, noninvasive, objective assessment of outcomes in living humans who have actually experienced the injury, or treatment being studied. The purpose of this study was to assess the validity of CT-based virtual mechanical testing with respect to physical biomechanical tests in a large animal model. Three different tibial osteotomy models were performed on 44 sheep. Data from 33 operated limbs and 20 intact limbs was retrospectively analyzed. Radiographic union scoring was performed on the operated limbs and physical torsional tests were performed on all limbs. Morphometric measures and finite element models were developed from CT scans and virtual torsional tests were performed to assess healing with four material assignment techniques. In correlation analysis, morphometric measures and radiographic scores were unreliable predictors of biomechanical rigidity, while the virtual torsion test results were strongly and significantly correlated with measured biomechanical test data, with high absolute agreement. Overall, the results validated the use of virtual mechanical testing as a reliable in vivo assessment of structural bone healing. This method is readily translatable to clinical evaluation for noninvasive assessment of the healing progress of fractures with minimal risk. Clinical significance: virtual mechanical testing can be used to reliably and noninvasively assess the rigidity of a healing fracture using clinical-resolution CT scans and that this measure is superior to morphometric and radiographic measures.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
computed tomography
en_US
dc.subject
finite element analysis
en_US
dc.subject
ovine osteotomy
en_US
dc.subject
tibial shaft fracture
en_US
dc.title
Virtual mechanical tests out-perform morphometric measures for assessment of mechanical stability of fracture healing in vivo
en_US
dc.type
Journal Article
dc.date.published
2020-09-24
ethz.journal.title
Journal of Orthopaedic Surgery and Research
ethz.journal.abbreviated
J. orthop. surg. res.
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Hoboken
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-10-17T02:41:42Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.exportRequired
true
ethz.COinS
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