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dc.contributor.author
Mante, Valerio
dc.contributor.author
Pillow, Jonathan W.
dc.contributor.author
Aoi, Mikio C.
dc.date.accessioned
2020-11-13T11:45:58Z
dc.date.available
2020-10-20T04:50:09Z
dc.date.available
2020-10-20T08:40:47Z
dc.date.available
2020-11-13T11:45:58Z
dc.date.issued
2020-11
dc.identifier.issn
1097-6256
dc.identifier.issn
1546-1726
dc.identifier.other
10.1038/s41593-020-0696-5
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/446716
dc.description.abstract
Recent work has suggested that the prefrontal cortex (PFC) plays a key role in context-dependent perceptual decision-making. In this study, we addressed that role using a new method for identifying task-relevant dimensions of neural population activity. Specifically, we show that the PFC has a multidimensional code for context, decisions and both relevant and irrelevant sensory information. Moreover, these representations evolve in time, with an early linear accumulation phase followed by a phase with rotational dynamics. We identify the dimensions of neural activity associated with these phases and show that they do not arise from distinct populations but from a single population with broad tuning characteristics. Finally, we use model-based decoding to show that the transition from linear to rotational dynamics coincides with a plateau in decoding accuracy, revealing that rotational dynamics in the PFC preserve sensory choice information for the duration of the stimulus integration period. Aoi et al. used a new dimensionality-reduction method to disentangle the contributions of different task variables to neural population activity, which revealed rotational dynamics in monkey PFC during context-dependent decision-making.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.title
Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making
en_US
dc.type
Journal Article
dc.date.published
2020-10-05
ethz.journal.title
Nature Neuroscience
ethz.journal.volume
23
en_US
ethz.journal.issue
11
en_US
ethz.journal.abbreviated
Nat. neurosci.
ethz.pages.start
1410
en_US
ethz.pages.end
1420
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-10-20T04:50:14Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-11-13T11:46:19Z
ethz.rosetta.lastUpdated
2022-03-29T04:01:51Z
ethz.rosetta.versionExported
true
ethz.COinS
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