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dc.contributor.author
Burdakov, Denis
dc.contributor.author
Karnani, Mahesh M.
dc.date.accessioned
2020-10-26T09:35:19Z
dc.date.available
2020-10-22T08:50:13Z
dc.date.available
2020-10-26T09:35:19Z
dc.date.issued
2020-10-19
dc.identifier.issn
0960-9822
dc.identifier.issn
1879-0445
dc.identifier.other
10.1016/j.cub.2020.07.061
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/447189
dc.identifier.doi
10.3929/ethz-b-000447189
dc.description.abstract
The lateral hypothalamic area (LH) is a vital controller of arousal, feeding, and metabolism [1, 2], which integrates external and internal sensory information. Whereas sensory and whole-body output properties of LH cell populations have received much interest, their intrinsic synaptic organization has remained largely unstudied. Local inhibitory and excitatory connections could help integrate and filter sensory information and mutually inhibitory connections [3] could allow coordinating activity between LH cell types, some of which have mutually exclusive behavioral effects, such as LH VGLUT2 and VGAT neurons [4, 5, 6, 7] and orexin- (ORX) and melanin-concentrating hormone (MCH) neurons [8, 9, 10]. However, classical Golgi staining studies did not find interneurons with locally ramifying axons in the LH [11, 12], and nearby subthalamic and thalamic areas lack local synaptic connectivity [13, 14]. Studies with optogenetic circuit mapping within the LH have demonstrated only a minority of connections when a large pool of presynaptic neurons was activated [15, 16, 17, 18, 19]. Because multiple patch clamp has not been used to study LH connectivity, aside from a limited dataset of MCH neurons where no connections were discovered [15], we used quadruple whole-cell recordings to screen connectivity within the LH with standard methodology we previously used in the neocortex [20, 21, 22]. Finding a lack of local connectivity, we used optogenetic circuit mapping to study the strength of LH optogenetic responses and network oscillations, which were consistent with ultra-sparse intrinsic connectivity within the LH. These results suggest that input from other brain structures is decisive for selecting active populations in the LH.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cell Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Lateral hypothalamus
en_US
dc.subject
Synaptic connectivity
en_US
dc.subject
Patch clamp
en_US
dc.subject
Orexin
en_US
dc.subject
MCH
en_US
dc.subject
Gamma oscillation
en_US
dc.title
Ultra-sparse Connectivity within the Lateral Hypothalamus
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-08-20
ethz.journal.title
Current Biology
ethz.journal.volume
30
en_US
ethz.journal.issue
20
en_US
ethz.journal.abbreviated
Curr Biol
ethz.pages.start
4063
en_US
ethz.pages.end
4070.e2
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge, MA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02542 - Institut für Neurowissenschaften / Institute for Neuroscience::09589 - Burdakov, Denis / Burdakov, Denis
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02542 - Institut für Neurowissenschaften / Institute for Neuroscience::09589 - Burdakov, Denis / Burdakov, Denis
ethz.date.deposited
2020-10-22T08:50:31Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-10-26T09:35:32Z
ethz.rosetta.lastUpdated
2021-02-15T19:19:10Z
ethz.rosetta.versionExported
true
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