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dc.contributor.author
Becker, Anton S.
dc.contributor.author
Zellweger, Caroline
dc.contributor.author
Bacanovic, Sara
dc.contributor.author
Franckenberg, Sabine
dc.contributor.author
Nagel, Hannes W.
dc.contributor.author
Frick, Lukas
dc.contributor.author
Schawkat, Khoschy
dc.contributor.author
Eberhard, Matthias
dc.contributor.author
Blüthgen, Christian
dc.contributor.author
Volbracht, Jörk
dc.contributor.author
Moos, Rudolf
dc.contributor.author
Wolfrum, Christian
dc.contributor.author
Burger, Irene A.
dc.date.accessioned
2021-03-04T10:48:45Z
dc.date.available
2020-10-23T02:55:32Z
dc.date.available
2020-10-23T08:27:05Z
dc.date.available
2021-03-04T10:48:45Z
dc.date.issued
2020
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0239990
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/447387
dc.identifier.doi
10.3929/ethz-b-000447387
dc.description.abstract
Background Brown adipose tissue (BAT) is a specialized form of adipose tissue, able to increase energy expenditure by heat generation in response to various stimuli. Recently, its pathological activation has been implicated in the pathogenesis of cancer cachexia. To establish a causal relationship, we retrospectively investigated the longitudinal changes in BAT and cancer in a large FDG-PET/CT cohort. Methods We retrospectively analyzed 13 461 FDG-PET/CT examinations of n = 8 409 patients at our institution from the winter months of 2007–2015. We graded the activation strength of BAT based on the anatomical location of the most caudally activated BAT depot into three tiers, and the stage of the cancer into five general grades. We validated the cancer grading by an interreader analysis and correlation with histopathological stage. Ambient temperature data (seven-day average before the examination) was obtained from a meteorological station close to the hospital. Changes of BAT, cancer, body mass index (BMI) and temperature between the different examinations were examined with Spearman’s test and a mixed linear model for correlation, and with a causal inference algorithm for causality. Results We found n = 283 patients with at least two examinations and active BAT in at least one of them. There was no significant interaction between the changes in BAT activation, cancer burden or BMI. Temperature changes exhibited a strong negative correlation with BAT activity (ϱ = -0.57, p<0.00001). These results were confirmed with the mixed linear model. Causal inference revealed a link of Temperature ➜ BAT in all subjects and also of BMI ➜ BAT in subjects who had lost weight and increased cancer burden, but no role of cancer and no causal links of BAT ➜ BMI. Conclusions Our data did not confirm the hypothesis that BAT plays a major role in cancer-mediated weight loss. Temperature changes are the main driver of incidental BAT activity on FDG-PET scans. © 2020 Public Library of Science
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dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
PLoS
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Brown fat does not cause cachexia in cancer patients: A large retrospective longitudinal FDG-PET/CT cohort study
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-10-08
ethz.journal.title
PLoS ONE
ethz.journal.volume
15
en_US
ethz.journal.issue
10
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e0239990
en_US
ethz.size
17 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03819 - Wolfrum, Christian / Wolfrum, Christian
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03819 - Wolfrum, Christian / Wolfrum, Christian
ethz.date.deposited
2020-10-23T02:55:39Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-10-23T08:27:18Z
ethz.rosetta.lastUpdated
2022-03-29T05:37:09Z
ethz.rosetta.versionExported
true
ethz.COinS
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