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dc.contributor.author
Gupta, Isha
dc.contributor.author
Cassará, Antonino M.
dc.contributor.author
Tarotin, Ilya
dc.contributor.author
Donega, Matteo
dc.contributor.author
Miranda, Jason A.
dc.contributor.author
Sokal, David M.
dc.contributor.author
Ouchouche, Sebastien
dc.contributor.author
Dopson, Wesley
dc.contributor.author
Matteucci, Paul
dc.contributor.author
Neufeld, Esra
dc.contributor.author
Schiefer, Matthew A.
dc.contributor.author
Rowles, Alison
dc.contributor.author
McGill, Paul
dc.contributor.author
Perkins, Justin
dc.contributor.author
Dolezalova, Nikola
dc.contributor.author
Saeb-Parsy, Kourosh
dc.contributor.author
Kuster, Niels
dc.contributor.author
Yazicioglu, Refet F.
dc.contributor.author
Witherington, Jason
dc.contributor.author
Chew, Daniel J.
dc.date.accessioned
2020-10-23T07:19:38Z
dc.date.available
2020-10-23T02:56:42Z
dc.date.available
2020-10-23T07:19:38Z
dc.date.issued
2020
dc.identifier.issn
2399-3642
dc.identifier.other
10.1038/s42003-020-01299-0
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/447392
dc.identifier.doi
10.3929/ethz-b-000447392
dc.description.abstract
Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents specific challenges in translating nerve stimulation parameters. Firstly, autonomic nerves are typically embedded non-uniformly among visceral and connective tissues with complex interfacing requirements. Secondly, these nerves contain axons with populations of varying phenotypes leading to complexities for axon engagement and activation. Thirdly, clinical translational of methodologies attained using preclinical animal models are limited due to heterogeneity of the intra- and inter-species comparative anatomy and physiology. Here we demonstrate how this can be accomplished by the use of in silico modelling of target anatomy, and validation of these estimations through ex vivo human tissue electrophysiology studies. Neuroelectrical models are developed to address the challenges in translation of parameters, which provides strong input criteria for device design and dose selection prior to a first-in-human trial.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-10-16
ethz.journal.title
Communications Biology
ethz.journal.volume
3
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Commun Biol
ethz.pages.start
577
en_US
ethz.size
11 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-10-23T02:56:48Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-10-23T07:19:51Z
ethz.rosetta.lastUpdated
2022-03-29T03:38:33Z
ethz.rosetta.versionExported
true
ethz.COinS
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