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dc.contributor.author
Ding, Yezhang
dc.contributor.author
Weckwerth, Philipp R.
dc.contributor.author
Poretsky, Elly
dc.contributor.author
Murphy, Katherine M.
dc.contributor.author
Sims, James
dc.contributor.author
Saldivar, Evan
dc.contributor.author
Christensen, Shawn A.
dc.contributor.author
Char, Si Nian
dc.contributor.author
Yang, Bing
dc.contributor.author
Tong, Anh-dao
dc.contributor.author
Shen, Zhouxin
dc.contributor.author
Kremling, Karl A.
dc.contributor.author
Buckler, Edward S.
dc.contributor.author
Kono, Tom
dc.contributor.author
Nelson, David R.
dc.contributor.author
Bohlmann, Jorg
dc.contributor.author
Bakker, Matthew G.
dc.contributor.author
Vaughan, Martha M.
dc.contributor.author
Khalil, Ahmed S.
dc.contributor.author
Betsiashvili, Mariam
dc.contributor.author
Dressano, Keini
dc.contributor.author
Köllner, Tobias G.
dc.contributor.author
Briggs, Steven P.
dc.contributor.author
Zerbe, Philipp
dc.contributor.author
Schmelz, Eric A.
dc.contributor.author
Huffaker, Alisa
dc.date.accessioned
2020-11-19T10:45:11Z
dc.date.available
2020-11-18T12:38:41Z
dc.date.available
2020-11-19T10:45:11Z
dc.date.issued
2020-11
dc.identifier.issn
2055-026X
dc.identifier.issn
2055-0278
dc.identifier.other
10.1038/s41477-020-00787-9
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/451874
dc.description.abstract
Specialized metabolites constitute key layers of immunity that underlie disease resistance in crops; however, challenges in resolving pathways limit our understanding of the functions and applications of these metabolites. In maize (Zea mays), the inducible accumulation of acidic terpenoids is increasingly considered to be a defence mechanism that contributes to disease resistance. Here, to understand maize antibiotic biosynthesis, we integrated association mapping, pan-genome multi-omic correlations, enzyme structure–function studies and targeted mutagenesis. We define ten genes in three zealexin (Zx) gene clusters that encode four sesquiterpene synthases and six cytochrome P450 proteins that collectively drive the production of diverse antibiotic cocktails. Quadruple mutants in which the ability to produce zealexins (ZXs) is blocked exhibit a broad-spectrum loss of disease resistance. Genetic redundancies ensuring pathway resiliency to single null mutations are combined with enzyme substrate promiscuity, creating a biosynthetic hourglass pathway that uses diverse substrates and in vivo combinatorial chemistry to yield complex antibiotic blends. The elucidated genetic basis of biochemical phenotypes that underlie disease resistance demonstrates a predominant maize defence pathway and informs innovative strategies for transferring chemical immunity between crops.
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.title
Genetic elucidation of interconnected antibiotic pathways mediating maize innate immunity
en_US
dc.type
Journal Article
dc.date.published
2020-10-26
ethz.journal.title
Nature Plants
ethz.journal.volume
6
en_US
ethz.journal.issue
11
en_US
ethz.journal.abbreviated
Nat Plants
ethz.pages.start
1375
en_US
ethz.pages.end
1388
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02703 - Institut für Agrarwissenschaften / Institute of Agricultural Sciences::03970 - De Moraes, Consuelo / De Moraes, Consuelo
ethz.date.deposited
2020-11-18T12:38:46Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-11-19T10:45:23Z
ethz.rosetta.lastUpdated
2024-02-02T12:31:03Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Genetic%20elucidation%20of%20interconnected%20antibiotic%20pathways%20mediating%20maize%20innate%20immunity&rft.jtitle=Nature%20Plants&rft.date=2020-11&rft.volume=6&rft.issue=11&rft.spage=1375&rft.epage=1388&rft.issn=2055-026X&2055-0278&rft.au=Ding,%20Yezhang&Weckwerth,%20Philipp%20R.&Poretsky,%20Elly&Murphy,%20Katherine%20M.&Sims,%20James&rft.genre=article&rft_id=info:doi/10.1038/s41477-020-00787-9&
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