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dc.contributor.author
Uhler, Caroline
dc.contributor.author
Shivashankar, G.V.
dc.date.accessioned
2020-12-07T10:36:09Z
dc.date.available
2020-12-05T03:49:11Z
dc.date.available
2020-12-07T10:36:09Z
dc.date.issued
2021-02
dc.identifier.issn
1359-0286
dc.identifier.issn
1879-0348
dc.identifier.other
10.1016/j.cossms.2020.100874
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/454785
dc.description.abstract
In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of diseases and potentially also play a critical role in host-pathogen interactions. In light of the current SARS-CoV-2 pandemic, we here highlight the possible role of lung tissue stiffening with ageing and how this might facilitate increased SARS-CoV-2 replication through matrix-stiffness dependent epithelial-to-mesenchymal transitions of the lung epithelium. This emphasizes the need for integrating material properties of tissues in drug discovery programs. © 2020 Elsevier Ltd.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.title
Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity
en_US
dc.type
Journal Article
dc.date.published
2020-11-06
ethz.journal.title
Current Opinion in Solid State & Materials Science
ethz.journal.volume
25
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
100874
en_US
ethz.size
4 p.
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Kidlington
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2020-12-05T03:49:16Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-12-07T10:36:23Z
ethz.rosetta.lastUpdated
2020-12-07T10:36:23Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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