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dc.contributor.author
Herter-Aeberli, Isabelle
dc.contributor.author
Wehrli, Nina
dc.contributor.author
Bärlocher, Kurt
dc.contributor.author
Andersson, Maria
dc.contributor.author
Sych, Janice
dc.date.accessioned
2020-12-14T12:01:58Z
dc.date.available
2020-12-13T04:14:09Z
dc.date.available
2020-12-14T12:01:58Z
dc.date.issued
2020-12
dc.identifier.other
10.3390/nu12123729
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/456118
dc.identifier.doi
10.3929/ethz-b-000456118
dc.description.abstract
Background: Folate plays an essential role in the prevention of neural tube defects, yet little is known about the folate status of women of reproductive age or to what degree the general population is aware of the importance of folate in early-life development. We aimed to determine folate status in women of reproductive age and pregnant women in Switzerland, and to assess folate awareness in the Swiss population. Methods: In a convenience sample of 171 women of reproductive age and 177 pregnant women throughout Switzerland, we measured red blood cell (RBC) folate concentration. In a second convenience sample (n = 784, men and women) we assessed folate knowledge with an online survey. Results: RBC folate concentration (median interquartile range) was 442 (366, 564) nmol/L in women of reproductive age and 873 (677, 1177) nmol/L in pregnant women. Folate deficiency (RBC folate <340 nmol/L) was found in 19.9% of women of reproductive age and 2.8% of pregnant women, while 91.8% of women of reproductive age and 52.0% of pregnant women showed folate concentrations indicating an elevated risk of neural tube defects (RBC folate <906 nmol/L). The online survey showed that a high proportion (≥88%) of participants were aware of folate’s role in neural tube defect (NTD) prevention and fetal development, yet knowledge about dietary sources and national recommendations of folate supplementation when planning pregnancy were limited. Conclusion: The high prevalence of folate inadequacy in Swiss women suggests an elevated risk of neural tube defects and calls for urgent measures to increase folate intakes.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
folate status
en_US
dc.subject
folic acid
en_US
dc.subject
women
en_US
dc.subject
pregnancy
en_US
dc.subject
folate awareness
en_US
dc.subject
neural tube defects
en_US
dc.title
Inadequate Status and Low Awareness of Folate in Switzerland—A Call to Strengthen Public Health Measures to Ensure Sufficient Intakes
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-12-03
ethz.journal.title
Nutrients
ethz.journal.volume
12
en_US
ethz.journal.issue
12
en_US
ethz.pages.start
3729
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03957 - Zimmermann, Michael Bruce / Zimmermann, Michael Bruce
ethz.date.deposited
2020-12-13T04:14:13Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-12-14T12:02:21Z
ethz.rosetta.lastUpdated
2021-02-15T22:11:40Z
ethz.rosetta.versionExported
true
ethz.COinS
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