Structure of native glycolipoprotein filaments in honeybee royal jelly
dc.contributor.author
Mattei, Simone
dc.contributor.author
Ban, Arvid
dc.contributor.author
Picenoni, Armin
dc.contributor.author
Leibundgut, Marc
dc.contributor.author
Glockshuber, Rudi
dc.contributor.author
Boehringer, Daniel
dc.date.accessioned
2020-12-15T07:41:26Z
dc.date.available
2020-12-15T03:20:20Z
dc.date.available
2020-12-15T07:41:26Z
dc.date.issued
2020
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/s41467-020-20135-x
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/456281
dc.identifier.doi
10.3929/ethz-b-000456281
dc.description.abstract
Royal jelly (RJ) is produced by honeybees (Apis mellifera) as nutrition during larval development. The high viscosity of RJ originates from high concentrations of long lipoprotein filaments that include the glycosylated major royal jelly protein 1 (MRJP1), the small protein apisimin and insect lipids. Using cryo-electron microscopy we reveal the architecture and the composition of RJ filaments, in which the MRJP1 forms the outer shell of the assembly, surrounding stacked apisimin tetramers harbouring tightly packed lipids in the centre. The structural data rationalize the pH-dependent disassembly of RJ filaments in the gut of the larvae.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Structure of native glycolipoprotein filaments in honeybee royal jelly
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-12-08
ethz.journal.title
Nature Communications
ethz.journal.volume
11
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
6267
en_US
ethz.size
7 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02521 - Inst. f. Molekularbiologie u. Biophysik / Inst. Molecular Biology and Biophysics::03412 - Glockshuber, Rudolf / Glockshuber, Rudolf
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02521 - Inst. f. Molekularbiologie u. Biophysik / Inst. Molecular Biology and Biophysics::03412 - Glockshuber, Rudolf / Glockshuber, Rudolf
ethz.date.deposited
2020-12-15T03:20:27Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-12-15T07:41:38Z
ethz.rosetta.lastUpdated
2024-02-02T12:41:07Z
ethz.rosetta.versionExported
true
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