Metadata only
Date
2021-03-01Type
- Journal Article
Citations
Cited 15 times in
Web of Science
Cited 19 times in
Scopus
ETH Bibliography
yes
Altmetrics
Abstract
Nucleoprotein (N) is an immunodominant antigen in many enveloped virus infections. While the diagnostic value of anti-N antibodies is clear, their role in immunity is not. This is because while they are non-neutralising, they somehow clear infection by coronavirus, influenza and LCMV in vivo. Here, we show that anti-N immune protection is mediated by the cytosolic Fc receptor and E3 ubiquitin ligase TRIM21. Exploiting LCMV as a model system, we demonstrate that TRIM21 uses anti-N antibodies to target N for cytosolic degradation and generate cytotoxic T cells (CTLs) against N peptide. These CTLs rapidly eliminate N-peptide-displaying cells and drive efficient viral clearance. These results reveal a new mechanism of immune synergy between antibodies and T cells and highlights N as an important vaccine target. Show more
Publication status
publishedExternal links
Journal / series
The EMBO JournalVolume
Pages / Article No.
Publisher
WileySubject
antibody; non-neutralising; nucleoprotein; TRIM21; virusOrganisational unit
03625 - Oxenius, Annette / Oxenius, Annette
More
Show all metadata
Citations
Cited 15 times in
Web of Science
Cited 19 times in
Scopus
ETH Bibliography
yes
Altmetrics