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dc.contributor.author
Pereira, Danilo
dc.contributor.author
McDonald, Bruce
dc.contributor.author
Croll, Daniel
dc.date.accessioned
2020-12-22T11:00:56Z
dc.date.available
2020-12-22T03:42:38Z
dc.date.available
2020-12-22T11:00:56Z
dc.date.issued
2020-12
dc.identifier.issn
1759-6653
dc.identifier.other
10.1093/gbe/evaa203
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/457969
dc.identifier.doi
10.3929/ethz-b-000457969
dc.description.abstract
Containing fungal diseases often depends on the application of fungicidal compounds. Fungicides can rapidly lose effectiveness due to the rise of resistant individuals in populations. However, the lack of knowledge about resistance mutations beyond known target genes challenges investigations into pathways to resistance. We used whole-genome sequencing data and association mapping to reveal the multilocus genetic architecture of fungicide resistance in a global panel of 159 isolates of Parastagonospora nodorum, an important fungal pathogen of wheat. We found significant differences in azole resistance among global field populations. The populations evolved distinctive combinations of resistance alleles which can interact when co-occurring in the same genetic background. We identified 34 significantly associated single nucleotide polymorphisms located in close proximity to genes associated with fungicide resistance in other fungi, including a major facilitator superfamily transporter. Using fungal colony growth rates and melanin production at different temperatures as fitness proxies, we found no evidence that resistance was constrained by genetic trade-offs. Our study demonstrates how genome-wide association studies of a global collection of pathogen strains can recapitulate the emergence of fungicide resistance. The distinct complement of resistance mutations found among populations illustrates how the evolutionary trajectory of fungicide adaptation can be complex and challenging to predict.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
The Genetic Architecture of Emerging Fungicide Resistance in Populations of a Global Wheat Pathogen
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-09-28
ethz.journal.title
Genome Biology and Evolution
ethz.journal.volume
12
en_US
ethz.journal.issue
12
en_US
ethz.journal.abbreviated
Genome Biol Evol
ethz.pages.start
2231
en_US
ethz.pages.end
2244
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
ethz.date.deposited
2020-12-22T03:42:45Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-12-22T11:01:05Z
ethz.rosetta.lastUpdated
2022-03-29T04:39:05Z
ethz.rosetta.versionExported
true
ethz.COinS
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